Abstract
SUMMARY: When the guanine analogue, 5-amino-7-hydroxy-1-v-triazolo (d) pyrimidine (guanazolo), was sprayed on the leaves of tobacco or Nicotiana glutinosa plants it reduced the number of local lesions and delayed or inhibited systemic spread of lucerne mosaic virus. Guanazolo was more effective when applied before inoculation, but had some effect if applied up to about the second day after inoculation. The compound was more effective in solution in 0·1% sodium bicarbonate than in aqueous suspension. With mechanically inoculated plants guanazolo watered on the soil around the plants was less effective than when sprayed on the leaves. Incubated with the virus in vitro the compound did not affect infectivity. In concentrations up to c. 0·005m guanazolo usually caused negligible plant damage, but at higher concentrations produced a slight yellowing and distortion in the younger leaves with general stunting if treatments were prolonged. The virus-inhibitory activity of guanazolo was reversed by adenine, guanine and possibly by hypoxanthine, but not by xanthine, uric acid, theobromine, theophylline, caffeine, uracil or thymine. The triazolo analogue of adenine severely damaged plants and had only slight virus inhibitory activity. The hypoxanthine analogue caused no plant damage. It was less effective than guanazolo in tobacco and N. glutinosa but more effective in reducing the number of local lesions produced in beans. Thiouracil, methyl-thiouracil and propylthiouracil were ineffective against lucerne mosaic virus. Thiouracil caused fairly severe plant damage. Guanazolo had slight or negligible effects on spotted wilt virus in tomato, potato viruses X and Y in potato, and tobacco and pea mosaic virus in peas. Applied as a leaf spray at 0·01m concentration guanazolo delayed or prevented systemic movement of cucumber mosaic virus from mechanically inoculated cucumber leaves, but had no effect when watered on the soil. However, watering the compound on the soil gave some control when the virus was introduced by aphids.
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Claims 20
Claim · model-written summary
Sprayed guanazolo reduced local lesions and delayed or inhibited lucerne mosaic virus spread in tobacco.
- Taxon
- tobacco
Nicotiana tabacume0 - Treatment
- guanazoloe0
- Interactor
- lucerne mosaic viruse0pathogen
- Outcome
- number of local lesionse0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“guanazolo), was sprayed on the leaves of tobacco or Nicotiana glutinosa plants it reduced the number of local lesions and delayed or inhibited systemic spread of lucerne mosaic virus”
Claim · model-written summary
Sprayed guanazolo reduced local lesions and delayed or inhibited lucerne mosaic virus spread in Nicotiana glutinosa.
- Taxon
- Nicotiana glutinosa
Nicotiana glutinosae0 - Treatment
- guanazoloe0
- Interactor
- lucerne mosaic viruse0pathogen
- Outcome
- number of local lesionse0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“guanazolo), was sprayed on the leaves of tobacco or Nicotiana glutinosa plants it reduced the number of local lesions and delayed or inhibited systemic spread of lucerne mosaic virus”
Claim · model-written summary
Guanazolo was more effective before inoculation than after it.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- Guanazoloe0
- Outcome
- more effectivee0
- Direction
- more effectivee0
- Qualifier
- before inoculatione0
- Comparator
- up to about the second day after inoculatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Guanazolo was more effective when applied before inoculation, but had some effect if applied up to about the second day after inoculation”
e1“leaves of tobacco”
Claim · model-written summary
Guanazolo in sodium bicarbonate solution was more effective than in aqueous suspension.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- solution in 0·1% sodium bicarbonatee0
- Outcome
- more effectivee0
- Direction
- more effectivee0
- Comparator
- aqueous suspensione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The compound was more effective in solution in 0·1% sodium bicarbonate than in aqueous suspension”
e1“leaves of tobacco”
Claim · model-written summary
Soil watered guanazolo was less effective than a leaf spray on mechanically inoculated plants.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- guanazolo watered on the soile0
- Outcome
- less effectivee0
- Direction
- less effectivee0
- Comparator
- sprayed on the leavese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“With mechanically inoculated plants guanazolo watered on the soil around the plants was less effective than when sprayed on the leaves”
e1“leaves of tobacco”
Claim · model-written summary
Guanazolo did not change viral infectivity after incubation in vitro.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- the compounde0
- Interactor
- lucerne mosaic viruse2pathogen
- Outcome
- infectivitye0
- Direction
- did not affecte0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Incubated with the virus in vitro the compound did not affect infectivity”
e1“leaves of tobacco”
e2“systemic spread of lucerne mosaic virus”
Claim · model-written summary
Guanazolo at concentrations up to about 0.005m usually caused negligible plant damage.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- c. 0·005m guanazoloe0
- Outcome
- plant damagee0
- Direction
- negligiblee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In concentrations up to c. 0·005m guanazolo usually caused negligible plant damage”
e1“leaves of tobacco”
Claim · model-written summary
Higher concentrations of guanazolo caused slight yellowing and distortion of younger leaves, with stunting under prolonged treatment.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- higher concentrationse0
- Outcome
- slight yellowing and distortion in the younger leavese0
- Qualifier
- if treatments were prolongede0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“at higher concentrations produced a slight yellowing and distortion in the younger leaves with general stunting if treatments were prolonged”
e1“leaves of tobacco”
Claim · model-written summary
Adenine and guanine reversed the virus inhibitory activity of guanazolo.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- adenine, guaninee0
- Outcome
- virus-inhibitory activity of guanazoloe0
- Direction
- reversede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The virus-inhibitory activity of guanazolo was reversed by adenine, guanine and possibly by hypoxanthine”
e1“leaves of tobacco”
Claim · model-written summary
The triazolo analogue of adenine severely damaged plants and had slight antiviral activity.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- triazolo analogue of adeninee0
- Outcome
- damaged plantse0
- Direction
- severelye0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The triazolo analogue of adenine severely damaged plants and had only slight virus inhibitory activity”
e1“leaves of tobacco”
Claim · model-written summary
The hypoxanthine analogue caused no plant damage.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- hypoxanthine analoguee0
- Outcome
- plant damagee0
- Direction
- noe0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The hypoxanthine analogue caused no plant damage”
e1“leaves of tobacco”
Claim · model-written summary
The hypoxanthine analogue was less effective than guanazolo in tobacco.
- Taxon
- tobaccoNicotiana tabacume0
- Treatment
- Ite0
- Outcome
- less effectivee0
- Direction
- less effectivee0
- Comparator
- guanazoloe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“It was less effective than guanazolo in tobacco and N. glutinosa”
Claim · model-written summary
The hypoxanthine analogue was less effective than guanazolo in N. glutinosa.
- Taxon
- N. glutinosaNicotiana glutinosae0
- Treatment
- Ite0
- Outcome
- less effectivee0
- Direction
- less effectivee0
- Comparator
- guanazoloe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“It was less effective than guanazolo in tobacco and N. glutinosa”
Claim · model-written summary
The hypoxanthine analogue reduced local lesions in beans more effectively than guanazolo.
Verbatim
e0“more effective in reducing the number of local lesions produced in beans”
e1“less effective than guanazolo”
e2“The hypoxanthine analogue”
Claim · model-written summary
Thiouracil, methyl-thiouracil and propylthiouracil were ineffective against lucerne mosaic virus.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- Thiouracil, methyl-thiouracil and propylthiouracile0
- Interactor
- lucerne mosaic viruse0pathogen
- Outcome
- ineffective against lucerne mosaic viruse0
- Direction
- ineffectivee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Thiouracil, methyl-thiouracil and propylthiouracil were ineffective against lucerne mosaic virus”
e1“leaves of tobacco”
Claim · model-written summary
Thiouracil caused fairly severe plant damage.
- Taxon
- tobaccoNicotiana tabacume1
- Treatment
- Thiouracile0
- Outcome
- plant damagee0
- Direction
- severee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Thiouracil caused fairly severe plant damage”
e1“leaves of tobacco”
Claim · model-written summary
Guanazolo had slight or negligible effects on spotted wilt virus in tomato.
- Taxon
- tomato
Solanum lycopersicume0 - Treatment
- Guanazoloe0
- Interactor
- spotted wilt viruse0pathogen
- Outcome
- effects on spotted wilt viruse0
- Direction
- slight or negligiblee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Guanazolo had slight or negligible effects on spotted wilt virus in tomato”
Claim · model-written summary
Guanazolo had slight or negligible effects on potato viruses X and Y in potato.
- Taxon
- potato
Solanum tuberosume0 - Treatment
- Guanazoloe0
- Interactor
- potato viruses X and Ye0pathogen
- Outcome
- potato viruses X and Ye0
- Direction
- slight or negligiblee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Guanazolo had slight or negligible effects on spotted wilt virus in tomato, potato viruses X and Y in potato”
Claim · model-written summary
A 0.01m guanazolo leaf spray delayed or prevented systemic movement of cucumber mosaic virus in cucumber.
- Taxon
- cucumber
Cucumis sativuse0 - Treatment
- leaf spray at 0·01m concentration guanazoloe0
- Interactor
- cucumber mosaic virus
cucumber mosaic cucumoviruse0pathogen - Outcome
- systemic movement of cucumber mosaic viruse0
- Direction
- delayed or preventede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Applied as a leaf spray at 0·01m concentration guanazolo delayed or prevented systemic movement of cucumber mosaic virus from mechanically inoculated cucumber leaves”
Claim · model-written summary
Soil watered guanazolo gave some control of aphid introduced cucumber mosaic virus.
- Taxon
- cucumberCucumis sativuse1
- Treatment
- watering the compound on the soile0
- Interactor
- cucumber mosaic viruscucumber mosaic cucumoviruse1pathogen
- Outcome
- some controle0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“watering the compound on the soil gave some control when the virus was introduced by aphids”
e1“cucumber mosaic virus from mechanically inoculated cucumber leaves”
The same questions in other papers
adenine · molecular: metabolites · Nicotiana tabacum (tobacco)Positive and negative results
2 in the opposite direction
- positive
- positive
thiouracil · disease · Nicotiana tabacum (tobacco)Positive and negative results
2 in the opposite direction
- positive
- positive
8-azaguanine · disease · Nicotiana tabacum (tobacco)Results agree
1 paper in the same direction as this paper
- positive
application · cucumber mosaic cucumovirus · Cucumis sativus (cucumber)Results agree
2 papers in the same direction as this paper
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.