Abstract
The majority of biological traits are genetically complex. Mapping the quantitative trait loci (QTL) that determine these phenotypes is a powerful means for estimating many parameters of the genetic architecture for a trait and potentially identifying the genes responsible for natural variation. Typically, such experiments are conducted in a single mapping population and, therefore, have only the potential to reveal genomic regions that are polymorphic between the progenitors of the population. What remains unclear is how well the QTL identified in any one mapping experiment characterize the genetics that underlie natural variation in traits. Here we provide QTL mapping data for trichome density from four recombinant inbred mapping populations of Arabidopsis thaliana. By aligning the linkage maps for these four populations onto a common physical map, the results from each experiment were directly compared. Seven of the nine QTL identified are population specific while two were mapped in all four populations. Our results show that many lineage-specific alleles that either increase or decrease trichome density persist in natural populations and that most of this genetic variation is additive. More generally, these findings suggest that the use of multiple populations holds great promise for better understanding the genetic architecture of natural variation.
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Claims 6
Claim · model-written summary
Seven of nine trichome-density QTL were population-specific.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Outcome
- QTL identified are population specifice0
- Value
- Seven of the nine QTLe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Seven of the nine QTL identified are population specific”
t0“Arabidopsis thaliana”
Claim · model-written summary
Two trichome-density QTL mapped in all four populations.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Outcome
- mapped in all four populationse0
- Value
- twoe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“two were mapped in all four populations”
t0“Arabidopsis thaliana”
Claim · model-written summary
Lineage-specific alleles that increase trichome density persist in natural populations.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- lineage-specific allelese0
- Outcome
- trichome densitye0
- Direction
- increasee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“many lineage-specific alleles that either increase or decrease trichome density persist in natural populations”
t0“Arabidopsis thaliana”
Claim · model-written summary
Lineage-specific alleles that decrease trichome density persist in natural populations.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- lineage-specific allelese0
- Outcome
- trichome densitye0
- Direction
- decreasee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“many lineage-specific alleles that either increase or decrease trichome density persist in natural populations”
t0“Arabidopsis thaliana”
Claim · model-written summary
Most genetic variation in trichome density was additive.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Outcome
- genetic variation is additivee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“most of this genetic variation is additive”
t0“Arabidopsis thaliana”
Claim · model-written summary
The authors conclude multiple populations help characterize the genetic architecture of natural variation.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Outcome
- use of multiple populationse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the use of multiple populations holds great promise for better understanding the genetic architecture of natural variation”
t0“Arabidopsis thaliana”