Abstract
The aim of the study is to establish a new method of quality evaluation and validate its feasibilities by the simultaneous quantitative assay of four lignanoids in Schisandra chinensis. A new quality evaluation method, quantitative analysis of multi-components by single marker (QAMS), was established and validated with Schisandra chinensis. Four main lignanoids, schisandrin, schisantherin A, deoxyschizandrin and gamma-schizandrin, were selected as analytes and schisandrin as internal reference substance to evaluate the quality. Their contents in 13 different batches of samples, collected from different bathes, were determined by both external standard method and QAMS. The method was evaluated by comparison of the quantitative results between external standard method and QAMS. No significant differences were found in the quantitative results of four lignanoids in 13 batches of S. chinensis determined by external standard method and QAMS. QAMS is feasible for determination of four lignanoids simultaneously when some authentic standard substances were unavailable, and the developed method can be used for quality control of S. chinensis.
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Claims 3
Claim · model-written summary
QAMS and the external standard method yielded no significant differences for four lignanoids in 13 S. chinensis batches.
- Taxon
- S. chinensis
Schisandra chinensise0 - Outcome
- quantitative results of four lignanoidse0
- Direction
- No significant differencese0
- Value
- 13 batchese0
- Comparator
- external standard methode0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“No significant differences were found in the quantitative results of four lignanoids in 13 batches of S. chinensis determined by external standard method and QAMS”
Claim · model-written summary
QAMS was judged feasible for simultaneous determination of four lignanoids when authentic standards were unavailable.
- Taxon
- Schisandra chinensisSchisandra chinensist0
- Outcome
- determination of four lignanoids simultaneouslye0
- Value
- four lignanoidse0
- Qualifier
- when some authentic standard substances were unavailablee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“QAMS is feasible for determination of four lignanoids simultaneously when some authentic standard substances were unavailable”
t0“Schisandra chinensis”
Claim · model-written summary
The authors propose QAMS for quality control of S. chinensis.
- Taxon
- S. chinensisSchisandra chinensise0
- Outcome
- can be used for quality controle0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the developed method can be used for quality control of S. chinensis”