Abstract
The antifungal activity of griseofulvin was evaluated against phytopathogenic fungi including Fusarium moniliforme, Fusarium solani, Fusarium oxysporum and Colletotrichum truncatum. The greenhouse test was also made to evaluate the control efficiency of griseofulvin to eggplant powdery mildew. The results indicated griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test. Subsequently, five griseofulvin analogues were synthesized and evaluated for antifungal activities against the four fungi. The results showed that these compounds performed significantly different activities in comparison with griseofulvin. The inhibition mechanism and bioavailability of active analogues were taken to expound their different performance and relations of structure and activity. The solubility in different solvents of analogues and griseofulvin was roughly evaluated and compared.
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Claims 1
Claim · model-written summary
Griseofulvin efficiently controlled eggplant powdery mildew in a greenhouse test.
- Taxon
- eggplant
Solanum melongenae0 - Treatment
- griseofulvine0
- Outcome
- eggplant powdery mildewe0
- Direction
- efficiently controle0
- Setting
- greenhouse teste0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test”