Paper · 2019 · Turkish Journal of Pharmaceutical Sciences

In Vitro Evaluation of the Chemical Composition and Various Biological Activities of Ficus carica Leaf Extracts

Mustafa ERGÜL; Merve ERGÜL; Nuraniye ERUYGUR; et al.

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Abstract

Ama: Bu almada, Ficus carica yapraklarna ait su ve metanol ekstrelerinin diyabet ve Alzheimer hastal ile ilikili enzimlerin inhibisyonu zerine etkisinin aratrlmas amalanmtr. Ayrca, ekstrelere ait biyoaktif bileenler, antikanser, antioksidan ve antimikrobiyal etkiler de aratrlmtr. Gere ve Yntemler: Ekstrelerdeki biyoaktif bileikler gaz kromatografisi-ktle spektrometresi metodu ile belirlenmitir. Antioksidan aktivite, 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6 sulphonic acid) (ABTS) radikal sprc, toplam fenol ve flavonoid ierii, ferrik indirgeme gc ve demir elasyon yntemleriyle deerlendirilmitir. Antikanser, antikolinesteraz ve antimikrobiyal etkinlikler ise srasyla XTT yntemi, Ellman yntemi ve mikrodilsyon teknii yntemi ile belirlenmitir. Bulgular: Elde ettiimiz sonular su ve metanol ekstreleri arasnda kimyasal bileim asndan farkllk olduunu ve her iki ekstrenin de gl antioksidan aktiviteye sahip olduunu gstermitir. Benzer ekilde, her iki ekstrede gl -

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