Abstract
Following the deregistration of lindane, several neonicotinoid insecticides have been registered as seed treatments for controlling wireworms in cereal crops. Unlike lindane, which did both, neonicotinoids provide crop protection but do not reduce wireworm populations. Hence populations of various economic species are growing in key wheat production areas of the United States and Canada, and there is a need for novel seed treatments that match the efficacy of lindane. Herein we evaluated broflanilide, a novel GABA-gated Cl- channel allosteric modulator that differs from the cyclodienes (e.g., lindane) in that it binds to a unique site in the GABA receptor. As such, broflanilide confers a new mode of insecticidal action (Group 30 MOA), and is the first meta-diamide insecticide developed. When evaluated in field trials over 7 yr at various rates, broflanilide at 5.0 g [AI]/100 kg wheat seed was as effective at protecting wheat stand from wireworm (Agriotes obscurus) injury as the current industry standard thiamethoxam at 20-30 g [AI]/100 kg seed. In addition, broflanilide at 5.0 g reduced neonate wireworms (produced from eggs laid in established wheat during the growing season) and resident wireworms (in the field at time of planting) by 73.1 and 81.1%, respectively, which is comparable to that reported for the previous industry standard lindane (75.3 and 57.6%, respectively). These studies show that broflanilide at 5.0 g [AI] will provide consistent wheat stand protection (equal to thiamethoxam at 20-30 g [AI]), and A. obscurus wireworm population reduction (equal to lindane at 59 g [AI]), and will do so at far lower dosages per hectare.
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Claims 5
Claim · model-written summary
Broflanilide at 5.0 g protected wheat stands as effectively as thiamethoxam at 20-30 g.
- Taxon
- wheat
Triticum aestivume0 - Treatment
- broflanilide at 5.0 g [AI]/100 kg wheat seede0
- Interactor
- Agriotes obscurus
Agriotes obscuruse0pest
- Outcome
- wheat stand from wireworm (Agriotes obscurus) injurye0
- Direction
- as effectivee0
- Comparator
- thiamethoxame0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“broflanilide at 5.0 g [AI]/100 kg wheat seed was as effective at protecting wheat stand from wireworm (Agriotes obscurus) injury as the current industry standard thiamethoxam at 20-30 g [AI]/100 kg seed”
Claim · model-written summary
Broflanilide reduced neonate wireworms by 73.1%.
- Taxon
- wheat
Triticum aestivume0 - Treatment
- broflanilide at 5.0 ge0
- Interactor
- Agriotes obscurus
Agriotes obscurust0pest
- Outcome
- neonate wirewormse0
- Direction
- reducede0
- Value
- 73.1e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“broflanilide at 5.0 g reduced neonate wireworms (produced from eggs laid in established wheat during the growing season) and resident wireworms (in the field at time of planting) by 73.1 and 81.1%, respectively”
t0“Wireworms (Agriotes obscurus)”
Claim · model-written summary
Broflanilide reduced resident wireworms by 81.1%.
- Taxon
- wheat
Triticum aestivume0 - Treatment
- broflanilide at 5.0 ge0
- Interactor
- Agriotes obscurus
Agriotes obscurust0pest
- Outcome
- resident wirewormse0
- Direction
- reducede0
- Value
- 81.1%e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“broflanilide at 5.0 g reduced neonate wireworms (produced from eggs laid in established wheat during the growing season) and resident wireworms (in the field at time of planting) by 73.1 and 81.1%, respectively”
t0“Wireworms (Agriotes obscurus)”
Claim · model-written summary
The authors conclude that broflanilide provides wheat stand protection equal to thiamethoxam at lower dosage.
- Taxon
- wheat
Triticum aestivume0 - Treatment
- broflanilide at 5.0 g [AI]e0
- Outcome
- consistent wheat stand protectione0
- Comparator
- thiamethoxame0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“These studies show that broflanilide at 5.0 g [AI] will provide consistent wheat stand protection (equal to thiamethoxam at 20-30 g [AI])”
e1“and will do so at far lower dosages per hectare.”
Claim · model-written summary
The authors conclude that broflanilide reduces A. obscurus populations as effectively as lindane at lower dosage.
- Taxon
- wheat
Triticum aestivume2 - Treatment
- broflanilide at 5.0 g [AI]e2
- Interactor
- A. obscurus
Agriotes obscuruse0pest
- Outcome
- A. obscurus wireworm population reductione0
- Comparator
- lindanee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“A. obscurus wireworm population reduction (equal to lindane at 59 g [AI])”
e1“and will do so at far lower dosages per hectare.”
e2“broflanilide at 5.0 g [AI] will provide consistent wheat stand protection”