Abstract
Background: Down syndrome (DS) is a most common cause of mental retardation in humans. Monitoring genetic damage in DS individuals helps in evaluating genetic damage. Micronucleus assay is potentially an excellent tool to serve as a biomarker which detects chromosomal loss or malfunction. Aim of the study: The objective of the study is to evaluate micronuclei (MN) frequency in exfoliated buccal cells in DS individuals. Materials and Methods: The study subjects consisted of clinically diagnosed cases of Down syndrome. Healthy subjects without any medical conditions formed the control group. The cyto-smears were stained with Papanicolaou stain.
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Claims 0
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