Abstract
Sarcopenia is a progressive muscle condition characterised by the degenerative decline in skeletal muscle mass and function which arises from immobility and ageing. It has become a global health crisis with the growing older population. Cistanches Herba (Rou Cong-Rong), holoparasitic plant of Cistanche deserticola, is classified as a kidney-tonifying agent in traditional Chinese medicine and is commonly used to treat infertility and muscle weakness. It has various pharmacological activities, such as anti-osteoporotic, antioxidative and neuroprotective effects. Acteoside is one of the bioactive compounds found in Cistanches Herba that may account for its protective effects in skeletal muscle. The aim of this study is to determine the myogenic effect of acteoside in C2C12 myoblasts. Acteoside at 500 nM could promote myogenic differentiation significantly in differentiating C2C12 myoblasts by increasing the number and area of myotubes by 17% and 18% respectively (p < 0.05). These results provide evidence for supporting the use of acteoside for and the management of sarcopenia. Further study will be needed to determine the in vivo effects of acteoside and Cistanches Herba in sarcopenic animal model and to evaluate the underlying mechanisms of their protective effects in skeletal muscle.
Abstract from the paper’s OpenAlex record; open copy licensed cc-by. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 0
Judged off_topic: human health or diet — claims were not extracted. This is a scope decision by the model, not a statement about the paper’s findings.