Abstract
BACKGROUND: Herbicides play an irreplaceable role in ensuring global food production and security. The low dispersion, non-uniform deposition, and negligible translocation of low water-soluble contact herbicides restrict the bioactivity. Therefore, there is an urgent need to develop novel, promising, and eco-friendly pesticide formulations to improve bioactivity and reduce the environmental input of herbicides. RESULTS: The diflufenican nanosuspension (NS) with satisfactory physical stability was prepared by wet media milling. The uniform deposition of diflufenican nanoparticles in NS on the surface of weed leaves improved the contact area with the target and enhanced the efficiency in penetrating the biological barrier. The indoor and field experiments showed that NS can exhibit comparable contact herbicidal activity against broadleaf weeds even with a 50% reduction in dosage compared to conventional pesticide formulations without negatively affecting the safety of wheat. The superior herbicidal activity of NS was due to its stronger ability to bind to the phytoene desaturase and prevent carotenoid biosynthesis, which further accelerated chlorophyll degradation. CONCLUSIONS: Our research represents an eco-friendly, low-cost, and scalable pathway for the efficient delivery of low water-soluble contact herbicides, which can provide practical support for reducing the environmental inputs and increasing the efficiency of contact herbicides. © 2025 Society of Chemical Industry.
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Claims 5
Claim · model-written summary
The diflufenican nanosuspension showed comparable contact herbicidal activity against broadleaf weeds with a 50% dose reduction compared with conventional formulations.
Verbatim
e1“The indoor and field experiments showed that NS can exhibit comparable contact herbicidal activity against broadleaf weeds even with a 50% reduction in dosage compared to conventional pesticide formulations without negatively affecting the safety of wheat”
Claim · model-written summary
The diflufenican nanosuspension did not negatively affect the safety of wheat.
- Taxon
- wheat
Triticum aestivume1 - Treatment
- NSe1
- Outcome
- safety of wheate1
- Direction
- without negatively affectinge1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e1“The indoor and field experiments showed that NS can exhibit comparable contact herbicidal activity against broadleaf weeds even with a 50% reduction in dosage compared to conventional pesticide formulations without negatively affecting the safety of wheat”
Claim · model-written summary
The superior herbicidal activity of the nanosuspension is attributed to stronger binding to phytoene desaturase, which prevents carotenoid biosynthesis and accelerates chlorophyll degradation.
Verbatim
e1“The indoor and field experiments showed that NS can exhibit comparable contact herbicidal activity against broadleaf weeds even with a 50% reduction in dosage compared to conventional pesticide formulations without negatively affecting the safety of wheat”
e3“The superior herbicidal activity of NS was due to its stronger ability to bind to the phytoene desaturase and prevent carotenoid biosynthesis, which further accelerated chlorophyll degradation”
Claim · model-written summary
The nanosuspension enhanced the efficiency of penetration of weed leaves through the biological barrier.
- Taxon
- weede2
- Treatment
- uniform deposition of diflufenican nanoparticles in NSe2
- Outcome
- efficiency in penetrating the biological barriere2
- Direction
- enhancede2
Not reportedComparator
Verbatim
e2“The uniform deposition of diflufenican nanoparticles in NS on the surface of weed leaves improved the contact area with the target and enhanced the efficiency in penetrating the biological barrier”
Claim · model-written summary
The nanosuspension improved the contact area between weed leaves and the target.
- Taxon
- weede2
- Treatment
- uniform deposition of diflufenican nanoparticles in NSe2
- Outcome
- contact area with the targete2
- Direction
- improvede2
Not reportedComparator
Verbatim
e2“The uniform deposition of diflufenican nanoparticles in NS on the surface of weed leaves improved the contact area with the target and enhanced the efficiency in penetrating the biological barrier”
The same questions in other papers
nanoparticle · organism · Triticum aestivum (wheat)Positive and negative results
3 papers in the same direction as this paper · 4 in the opposite direction
- positive
- positive
- positive
4 papers more in this group
See all 8 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.