Abstract
Rhizoctonia solani is a major soil-borne pathogen that causes severe agricultural damage to maize, rice, soybean, and potato. The increasing resistance of pathogens to conventional fungicides and environmental concerns necessitate the development of new, effective, and eco-friendly antifungal compounds. Guided by a comparative docking study, 5-substituted-1,3,4-thiadiazole-2-thiol derivatives were synthesized, characterized, and evaluated for their antifungal efficacy against R. solani . Several derivatives exhibited strong antifungal activity (EC 50: 3.6 to 196.56 μg/mL), particularly those with halogen-substituted phenyl rings. The compound, 5-((2,4-dichlorophenoxy)methyl)-1,3,4-thiadiazole-2-thiol (A-3), showed the highest activity comparable to the reference fungicide hexaconazole (EC 50 = 2.33 μg/mL). Structure–activity relationship analysis and ergosterol inhibition activity affirmed their potential as effective agricultural fungicides, while ECOSAR model predictions indicated their promise as environmentally safe bioactive compounds for plant disease management.
Abstract from the paper’s OpenAlex record, shown for indexing and research. Copyright remains with the authors or the publisher. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 0
Judged adjacent: pathogen biology without a host experiment — claims were not extracted. This is a scope decision by the model, not a statement about the paper’s findings.