Abstract
Lignans, as active components of Schisandra chinensis , exhibit hepatoprotective, antitumor, and antiviral pharmacological effects; however, the complexity and structural similarity of S. chinensis still result in technical bottlenecks for the efficient extraction of lignans. Thus, it is essential to develop a simple and efficient way for lignan extraction. In this paper, a magnetic cationic metal-organic framework (Fe 3 O 4 @iMOF-Co) was synthesized and applied to dispersive magnetic solid-phase extraction (DMSPE) technology, which possesses a unique positively charged framework as well as a magnetic response for specific enrichment of negatively charged lignans by electrostatic interactions and rapid separation. The prepared materials were characterized using various techniques. Under ideal DMSPE conditions, the HPLC-MS/MS approach exhibited strong linearity (R 2 ≥0.9951) and low detection limits (LOD) (0.08-0.33 μg⋅kg -1 ) for lignans. The DMSPE method has been effectively used for the extraction of lignans from actual S. chinensis samples with recoveries ranging from 86.2% to 113.4% and relative standard deviations (RSDs) below 7.3%. The above results indicate that the prepared nanoparticles have the advantages of a simple extraction method, high efficiency, and low solvent consumption. This provides efficient and feasible technological support for the development of S. chinensis functional foodstuffs or pharmacological efficacy and other studies. • A core-shell structured magnetic cation MOF (Fe 3 O 4 @iMOF-Co) was synthesized. • Fe 3 O 4 @iMOF-Co mainly adsorbs Schisandra chinensis through electrostatic effect. • The method has outstanding sensitivity, low detection limit, and excellent recovery rate. • The process has low solvent consumption, short extraction time and is green.
Abstract from the paper’s OpenAlex record; open copy licensed cc-by-nc-nd. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 4
Claim · model-written summary
The HPLC-MS/MS approach had linearity of R 2 ≥0.9951 for lignans.
- Taxon
- Schisandra chinensis
Schisandra chinensist0 - Outcome
- linearitye0
- Value
- R 2 ≥0.9951e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the HPLC-MS/MS approach exhibited strong linearity (R 2 ≥0.9951) and low detection limits (LOD) (0.08-0.33 μg⋅kg -1 ) for lignans.”
t0“Schisandra chinensis”
Claim · model-written summary
The method detected lignans at 0.08-0.33 μg⋅kg -1.
- Taxon
- Schisandra chinensisSchisandra chinensist0
- Outcome
- detection limits (LOD)e0
- Value
- 0.08-0.33 μg⋅kg -1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“low detection limits (LOD) (0.08-0.33 μg⋅kg -1 ) for lignans.”
t0“Schisandra chinensis”
Claim · model-written summary
Extraction recovery from S. chinensis samples ranged from 86.2% to 113.4%.
- Taxon
- S. chinensisSchisandra chinensise0
- Outcome
- recoveriese0
- Value
- 86.2% to 113.4%e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“extraction of lignans from actual S. chinensis samples with recoveries ranging from 86.2% to 113.4% and relative standard deviations (RSDs) below 7.3%.”
t0“Schisandra chinensis”
Claim · model-written summary
Extraction from S. chinensis samples had relative standard deviations below 7.3%.
- Taxon
- S. chinensisSchisandra chinensise0
- Outcome
- relative standard deviations (RSDs)e0
- Value
- 7.3%e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“actual S. chinensis samples with recoveries ranging from 86.2% to 113.4% and relative standard deviations (RSDs) below 7.3%.”
t0“Schisandra chinensis”