Abstract
Pseudomonas protegens CHA0 and other fluorescent pseudomonads suppress plant diseases by producing a number of metabolites with antibiotic activities in the rhizosphere. However, limited information is available on the physiological functions of most of these metabolites. We herein describe the detection of 3-mercaptopropionic acid (3-MPA), a thiol compound, based on the metabolome of the supernatant of strain CHA0. 3-MPA exhibited antibiotic activity against oomycete and fungal pathogens and suppressed Pythium damping-off and root rot in cucumber. 3-MPA also exhibited antibiotic activity without direct contact with pathogens, indicating the volatilization effect of this compound. We identified a homologous gene encoding 3-MPA dioxygenase in the CHA0 genome and the production level of 3-MPA was elevated in a 3mdo -negative mutant. Growth inhibitory activity against oomycete and fungal pathogens and plant protection efficacy exhibited by the 3mdo -negative mutant were stronger than those of wild-type CHA0. These results suggest that 3-MPA is biocontrol factor of strain CHA0.
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Claims 8
Claim · model-written summary
3-Mercaptopropionic acid (3-MPA), a thiol compound, was detected in the metabolome of the supernatant of strain CHA0.
- Outcome
- detection of 3-mercaptopropionic acid (3-MPA)e0
- Setting
- metabolome of the supernatant of strain CHA0e0
Not reportedTaxon
Verbatim
e0“We herein describe the detection of 3-mercaptopropionic acid (3-MPA), a thiol compound, based on the metabolome of the supernatant of strain CHA0”
Claim · model-written summary
3-MPA exhibited antibiotic activity against oomycete and fungal pathogens.
- Treatment
- 3-MPAe0
- Interactor
- oomycete and fungal pathogense0pathogen
- Outcome
- antibiotic activity against oomycete and fungal pathogense0
Not reportedTaxon
Verbatim
e0“3-MPA exhibited antibiotic activity against oomycete and fungal pathogens”
Claim · model-written summary
3-MPA suppressed Pythium damping-off and root rot in cucumber.
- Taxon
- cucumber
Cucumis sativuse0 - Treatment
- 3-MPAe0
- Outcome
- Pythium damping-off and root rote0
- Direction
- suppressede0
.jpg?width=60){kind=small}
PythiumNot reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“3-MPA exhibited antibiotic activity against oomycete and fungal pathogens and suppressed Pythium damping-off and root rot in cucumber”
Claim · model-written summary
3-MPA exhibited antibiotic activity without direct contact with pathogens, indicating a volatilization effect.
- Treatment
- 3-MPAe0
- Interactor
- pathogense0pathogen
- Outcome
- antibiotic activity without direct contact with pathogense0
Not reportedTaxon
Verbatim
e0“3-MPA also exhibited antibiotic activity without direct contact with pathogens, indicating the volatilization effect of this compound”
Claim · model-written summary
A homologous gene encoding 3-MPA dioxygenase was identified in the CHA0 genome.
Verbatim
e0“We identified a homologous gene encoding 3-MPA dioxygenase in the CHA0 genome”
Claim · model-written summary
3-MPA production was elevated in a 3mdo-negative mutant of CHA0.
Verbatim
e0“the production level of 3-MPA was elevated in a 3mdo -negative mutant”
e1“the CHA0 genome”
Claim · model-written summary
The 3mdo-negative mutant showed stronger growth inhibitory activity against oomycete and fungal pathogens and stronger plant protection efficacy than wild-type CHA0.
Verbatim
e0“Growth inhibitory activity against oomycete and fungal pathogens and plant protection efficacy exhibited by the 3mdo -negative mutant were stronger than those of wild-type CHA0”
Claim · model-written summary
The authors conclude that 3-MPA is a biocontrol factor of strain CHA0.
Verbatim
e0“These results suggest that 3-MPA is biocontrol factor of strain CHA0”