AaCBF4 4 claims

Literal values, not normalised. 326,269 distinct spellings cover 898,882 claims; only letter case and spacing are merged, so “maize”, “corn” and “Zea mays L.” are three separate entries here.

Functional evidence on CBF4

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

CBF4 · NCBI Gene 835274 ↗ · Open in the knowledge graph

Arabidopsis thaliana (thale cress)1 paper · 1 traitTested in one paper only

Only one paper in the store tests this gene's function in Arabidopsis thaliana (thale cress).

Cold tolerance1 paper

Promotes
AaCBF4 overexpression improved cold tolerance in Arabidopsis.
Genome-Wide Identification and Expression Divergence of CBF Family in Actinidia arguta and Functional Analysis of AaCBF4 Under Cold Stress · 2025
gain of function → more of the trait

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.

4 claims

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Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

AaCBF4 overexpression improved cold tolerance in Arabidopsis.

Taxon: ArabidopsisArabidopsist0
Treatment: AaCBF4-overexpressinge0
Gene: AaCBF4e0
Outcome: tolerance to cold stresse0
Direction: highere0

Not reportedComparator

Verbatim

e0
“AaCBF4-overexpressing plants showed higher tolerance to cold stress”
✓ located verbatim in the source · abstract, characters 1477–1544

t0
“transgenic Arabidopsis”
✓ located verbatim in the source · abstract, characters 1453–1475

Title

Genome-Wide Identification and Expression Divergence of CBF Family in Actinidia arguta and Functional Analysis of AaCBF4 Under Cold Stress

Sumei Li; Qina Zhang; Zhenzhen Zhang; et al. Life 2025. doi:10.3390/life15020227

Other claims from this paper (12)

Observation Eighteen CBF genes occurred on four chromosomes with five tandem repeats.
Observation CBF proteins were predicted in the nucleus and cytoplasm.
Observation CBF promoters contained light, temperature and hormone response elements.
Observation CBF family member count differed among geographic locations.
Intervention effect Low temperature changed expression of all CBF genes.
Observation AaCBF4 expression was highly upregulated.
Intervention effect AaCBF4 overexpression increased germination rate under cold stress.
Intervention effect AaCBF4 overexpression increased chlorophyll content under cold stress.
Intervention effect AaCBF4 overexpression decreased relative electrolyte leakage under cold stress.
Intervention effect Overexpressing Arabidopsis had significantly less oxidative damage than wild type under cold stress.
Intervention effect Overexpressing Arabidopsis produced less reactive oxygen species under cold stress.
Recommendation Authors propose AaCBF4 for cold resistant kiwifruit germplasm development.

Recommendationauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

Authors propose AaCBF4 for cold resistant kiwifruit germplasm development.

Taxon: Actinidia argutaActinidia argutae0
Gene: AaCBF4e0
Outcome: develop kiwifruit germplasm resources with strong cold resistancee0

Verbatim

e0
“AaCBF4 plays an important role in improving the cold resistance of Actinidia arguta and can be further used to develop kiwifruit germplasm resources with strong cold resistance.”
✓ located verbatim in the source · abstract, characters 1866–2043

Title

Genome-Wide Identification and Expression Divergence of CBF Family in Actinidia arguta and Functional Analysis of AaCBF4 Under Cold Stress

Sumei Li; Qina Zhang; Zhenzhen Zhang; et al. Life 2025. doi:10.3390/life15020227

Other claims from this paper (12)

Observation Eighteen CBF genes occurred on four chromosomes with five tandem repeats.
Observation CBF proteins were predicted in the nucleus and cytoplasm.
Observation CBF promoters contained light, temperature and hormone response elements.
Observation CBF family member count differed among geographic locations.
Intervention effect Low temperature changed expression of all CBF genes.
Observation AaCBF4 expression was highly upregulated.
Intervention effect AaCBF4 overexpression improved cold tolerance in Arabidopsis.
Intervention effect AaCBF4 overexpression increased germination rate under cold stress.
Intervention effect AaCBF4 overexpression increased chlorophyll content under cold stress.
Intervention effect AaCBF4 overexpression decreased relative electrolyte leakage under cold stress.
Intervention effect Overexpressing Arabidopsis had significantly less oxidative damage than wild type under cold stress.
Intervention effect Overexpressing Arabidopsis produced less reactive oxygen species under cold stress.

Associationobservedoriginal resultmeasured

Claim · model-written summary

AaCBF4 directly regulates AaBAM3.1 expression.

Taxon: kiwifruitActinidia deliciosat0
Gene: AaCBF4e2
Outcome: AaBAM3.1 expressione2
Direction: directly regulatede2

Verbatim

t0
“freezing tolerance of kiwifruit (Actinidia arguta)”
✓ located verbatim in the source · title, characters 36–86

e2
“AaCBF4 directly regulated AaBAM3.1 expression”
✓ located verbatim in the source · abstract, characters 880–925

Title

The AaCBF4-AaBAM3.1 module enhances freezing tolerance of kiwifruit (Actinidia arguta)

Shihang Sun; Chungen Hu; Xiujuan Qi; et al. Horticulture Research 2021. doi:10.1038/s41438-021-00530-1

Other claims from this paper (6)

Intervention effect AaBAM3.1-overexpressing kiwifruit lines had increased freezing tolerance.
Intervention effect Heterologous overexpression of AaBAM3.1 in Arabidopsis thaliana gave a similar phenotype.
Intervention effect AaBAM3.1 expression was induced by cold stress.
Association Expression of AaBAM3.1 and AaCBF4 in kiwifruit responded positively to cold stress.
Observation Promoter GUS and cis-element analyses predicted AaCBF4 to be an upstream transcription factor of AaBAM3.1.
Mechanism The AaCBF-AaBAM module positively regulates freezing tolerance of kiwifruit.

Observationhypothesisoriginal resultmeasured

Claim · model-written summary

Promoter GUS and cis-element analyses predicted AaCBF4 to be an upstream transcription factor of AaBAM3.1.

Taxon: kiwifruitActinidia deliciosat0
Gene: AaCBF4e5
Outcome: upstream transcription factore5

Verbatim

t0
“freezing tolerance of kiwifruit (Actinidia arguta)”
✓ located verbatim in the source · title, characters 36–86

e5
“The results of promoter GUS activity and cis-element analyses predicted AaCBF4 to be an upstream transcription factor that could regulate AaBAM3.1 expression”
✓ located verbatim in the source · abstract, characters 575–732

Title

The AaCBF4-AaBAM3.1 module enhances freezing tolerance of kiwifruit (Actinidia arguta)

Shihang Sun; Chungen Hu; Xiujuan Qi; et al. Horticulture Research 2021. doi:10.1038/s41438-021-00530-1

Other claims from this paper (6)

Intervention effect AaBAM3.1-overexpressing kiwifruit lines had increased freezing tolerance.
Intervention effect Heterologous overexpression of AaBAM3.1 in Arabidopsis thaliana gave a similar phenotype.
Association AaCBF4 directly regulates AaBAM3.1 expression.
Intervention effect AaBAM3.1 expression was induced by cold stress.
Association Expression of AaBAM3.1 and AaCBF4 in kiwifruit responded positively to cold stress.
Mechanism The AaCBF-AaBAM module positively regulates freezing tolerance of kiwifruit.