Environmental variation enabled detection of rate-limiting transcriptional steps for CGA biosynthesis.

Claim · model-written summary

Environmental variation enabled detection of rate-limiting transcriptional steps for CGA biosynthesis.

Taxon

Coffea arabicaCoffea arabicae0

Outcome

detection of rate-limiting transcriptional stepse2

Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim

e0

“Developing Coffea arabica seeds accumulate large amounts of chlorogenic acids (CGAs) as a storage form of phenylpropanoid derivatives”

e1

“Although CGA metabolism was controlled by major developmental factors, the mean temperature during seed development had a direct impact on the time-window of CGA biosynthesis, as well as on final CGA isomer composition through subtle transcriptional regulations.”

e2

“We provide evidence that the variability induced by the environment is a useful tool to test whether CGA accumulation is quantitatively modulated at the transcriptional level, hence enabling detection of rate-limiting transcriptional steps [quantitative trait transcripts (QTTs)] for CGA biosynthesis.”

e3

“Variations induced by the environment also enabled a better description of the phenylpropanoid gene transcriptional network throughout seed development, as well as the detection of three temporally distinct modules of quantitatively co-expressed genes.”

e4

“Finally, analysis of metabolite-to-metabolite relationships revealed new biochemical characteristics of the isomerization steps that remain uncharacterized at the gene level.”