Claim · model-written summary
The fdm1 and fdm2 double mutations released transcriptional gene silencing.
- Taxon
- Arabidopsis
Arabidopsise0 - Treatment
- fdm1 and fdm2 double mutationse2
- Outcome
- transcriptional gene silencinge3
- Direction
- releasee3
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“release transcriptional gene silencing and dramatically reduce the abundance of siRNAs originated from high copy number repeats or transposons”
e2“The fdm1 and fdm2 double mutations but not the fdm1 or fdm2 single mutations significantly impair DNA methylation at RdDM loci”
e0“Here, we show that a group of SGS3-like proteins act redundantly in RNA-directed DNA methylation (RdDM) pathway in Arabidopsis”
Title
A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation
Meng Xie; Guodong Ren; Pedro Costa-Nunes; et al. Nucleic Acids Research 2012. doi:10.1093/nar/gks034
Other claims from this paper (8)
- Association FDM1 and FDM2 expression is significantly correlated with known RdDM genes in Arabidopsis.
- Observation A group of SGS3-like proteins acts redundantly in RdDM in Arabidopsis.
- Intervention effect The fdm1 and fdm2 double mutations significantly impaired DNA methylation at RdDM loci relative to the fdm1 or fdm2 single mutations.
- Intervention effect The fdm1 or fdm2 single mutations did not significantly impair DNA methylation at RdDM loci.
- Intervention effect The fdm1 and fdm2 double mutations dramatically reduced the abundance of siRNAs originated from high copy number repeats or transposons.
- Observation FDM1 binds dsRNAs with 5' overhangs.
- Observation IDN2 and FDM3, FDM4 and FDM5 have overlapping function with FDM1 in RdDM.
- Observation Five FDM proteins and IDN2 define a group of SGS3-like proteins that possess all four-signature motifs in Arabidopsis.