Claim · model-written summary
Knockdown of ATG8h, ATG5 or ATG7 compromised C1 degradation.
- Taxon
- solanaceous plantst0
- Treatment
- ATG8h, ATG5, or ATG7 are knocked downe0
- Outcome
- compromisede0
- Direction
- compromisede0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Verbatim
e0“compromised when the autophagy-related genes (ATGs) ATG8h, ATG5, or ATG7 are knocked down”
t0“solanaceous plants”
Title
Fangfang Li; Mingzhen Zhang; Changwei Zhang; et al. New Phytologist 2019. doi:10.1111/nph.16268
Other claims from this paper (7)
- Observation Viral C1 induces autophagy and interacts with ATG8h.
- Mechanism ATG8h interaction relocates C1 and reduces its accumulation through exportin1.
- Intervention effect Autophagy inhibitors blocked C1 degradation.
- Intervention effect Silencing autophagy genes promoted TLCYnV infection in both plant species.
- Intervention effect The C1 AIM mutation abolished cytoplasmic ATG8h interaction.
- Intervention effect The C1 AIM mutation favored Fibrillarin1 interaction in the nucleolus.
- Intervention effect TLCYnV with AIM mutation had enhanced pathogenicity.