Claim · model-written summary
CRISPR mutagenesis of Trkin on Ab10 does not improve meiotic drive or fitness in maize.
Zea maysNot reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“In maize, there are 2 meiotic drive systems that target large heterochromatic knobs composed of tandem repeats known as knob180 and TR-1”
e3“We also carried out CRISPR mutagenesis to test the role of Trkin on Ab10 and K10L2”
e4“The data indicate that the Trkin gene on Ab10 does not improve drive or fitness”
Title
Conflicting Kinesin-14s in a single chromosomal drive haplotype
Meghan J Brady; Anjali Gupta; Jonathan I Gent; et al. Genetics 2025. doi:10.1093/genetics/iyaf091
Other claims from this paper (5)
- Observation The K10L2 haplotype has strong homology to an internal portion of the Ab10 haplotype.
- Intervention effect Trkin on Ab10 has a weak deleterious effect when paired with a normal chromosome 10 in maize.
- Intervention effect The deleterious effect of Ab10 is more severe when Ab10 is paired with K10L2 in maize.
- Intervention effect Functional Trkin on either chromosome nearly abolishes Ab10 drive in maize.
- Observation Modeling suggests that Trkin is unlikely to persist on Ab10.