Claim · model-written summary
Structural variants leading to genic hemizygosity were identified in the crop genomes.
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Verbatim
e0“We identified SVs leading to genic hemizygosity”
t0“crops”
Title
Yanling Peng; Yiwen Wang; Yuting Liu; et al. Proceedings of the National Academy of Sciences 2025. doi:10.1073/pnas.2422487122
Other claims from this paper (11)
- Observation Very few genes (0.01 to 1.2%) were hemizygous in the inbred, putatively homozygous genomes used as negative controls.
- Observation Hemizygosity was appreciable among outcrossed lineages, averaging 8.7% of genes.
- Association Hemizygosity was more elevated in clonal samples (13.8% of genes) than in outcrossed lineages.
- Mechanism The elevated hemizygosity in clonal samples likely reflects accumulation of heterozygous structural variants during clonal propagation.
- Association Hemizygous genes were situated more often in centromeric than telomeric regions than diploid genes were.
- Association Hemizygous genes experienced weaker purifying selection than diploid genes.
- Association Hemizygous genes had reduced expression, averaging about 20% of the expression levels of diploid genes.
- Observation The reduced expression of hemizygous genes violates the evolutionary model of dosage compensation.
- Association Higher DNA methylation levels were detected in hemizygous genes.
- Mechanism The higher DNA methylation may contribute to the reduced expression of hemizygous genes.
- Observation Hemizygous genes were more specifically expressed in contexts related to fruit development, organ differentiation and stress responses.