Abstract
OBJECTIVE: To investigate the chemical constituents with immunosuppressive function from Alisma orientalis. METHOD: The chemical constituents were isolated and purified by kinds of column chromatography and its structures were elucidated by NMR spectra and physicochemical properties. Its immunocompentence of lymphocytes taken from spleen of mouse were examined by MTT assay. RESULT: Twelve compounds were isolated and identified as clovandiol (1), orientalol E (2), alismoxide (3), alismol (4), 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en (5), alismorientols A (6), alisol F (7), alisol A (8), 13beta,17beta-epoxy alisol A (9), alisol B 23-acetate (10), 1H-indole-3-carboxylic acid (11) and cuccinic acid (12). Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function. CONCLUSION: Compounds 1, 5, 11 and 12 were isolated firstly from this genus,and the NMR spectra data of 1 were corrected firstly, some protostan-type triterpenoids may be developed as new drug with immunosuppressive function.
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Claims 10
Claim · model-written summary
Clovandiol, orientalol E, and alismoxide were isolated and identified from Alisma orientalis.
Verbatim
e0“clovandiol (1), orientalol E (2), alismoxide (3)”
t0“Alisma orientalis”
Claim · model-written summary
Alismol, 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en, and alismorientols A were isolated and identified from Alisma orientalis.
Verbatim
e0“alismol (4), 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en (5), alismorientols A (6)”
t0“Alisma orientalis”
Claim · model-written summary
Alisol F, alisol A, and 13beta,17beta-epoxy alisol A were isolated and identified from Alisma orientalis.
Verbatim
e0“alisol F (7), alisol A (8), 13beta,17beta-epoxy alisol A (9)”
t0“Alisma orientalis”
Claim · model-written summary
Alisol B 23-acetate, 1H-indole-3-carboxylic acid, and cuccinic acid were isolated and identified from Alisma orientalis.
Verbatim
e0“alisol B 23-acetate (10), 1H-indole-3-carboxylic acid (11) and cuccinic acid (12)”
t0“Alisma orientalis”
Claim · model-written summary
13beta,17beta-epoxy alisol A showed immunosuppressive function.
Not reportedMaterial
Verbatim
e0“13beta,17beta-epoxy alisol A (9)”
e1“Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function.”
t0“Alisma orientalis”
Claim · model-written summary
Alisol B 23-acetate showed immunosuppressive function.
Verbatim
e0“alisol B 23-acetate (10)”
e1“Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function.”
t0“Alisma orientalis”
Claim · model-written summary
Alisol A 24-acetate showed immunosuppressive function.
Verbatim
e0“alisol A 24-acetate showed immunosuppressive function”
t0“Alisma orientalis”
Claim · model-written summary
Compounds 1, 5, 11, and 12 were isolated from the genus for the first time.
Verbatim
e0“Compounds 1, 5, 11 and 12 were isolated firstly from this genus”
t0“Alisma orientalis”
Claim · model-written summary
The NMR spectrum data for compound 1 were corrected for the first time.
Not reportedComparatorValue
Verbatim
e0“the NMR spectra data of 1 were corrected firstly”
t0“Alisma orientalis”
Claim · model-written summary
The authors suggest some protostan-type triterpenoids as potential new immunosuppressive drugs.
Verbatim
e0“some protostan-type triterpenoids may be developed as new drug with immunosuppressive function”
t0“Alisma orientalis”