Abstract
In maize, certain enzyme and protein levels have been found to be negatively correlated with several segmental aneuploids (1-2-3 doses), with the extreme limits being the inverse of the dosage relative to the diploid. In fewer cases, positive correlations with chromosome dosage are observed. The levels of alcohol and glutamate dehydrogenases and one protein species, all with structural genes in IL, are compensated in a dosage series and at least in the case of ADH, this appears to be due to a cancellation of an inverse effect by a gene dosage effect in scutellar tissue. In Drosophila, the X chromosome has been divided into thirteen single or combined trisomic regions using X;4 and X;Y translocations with the following enzymes being studied: G6PDH, 6PGDH, ..beta..HAD, ..cap alpha..GPDH, IDH and ADH. Of the regions studied to date, multiple duplications in adult females specifically reduce one or more enzymes encoded by x or autosomal genes. The addition of the same duplications to males results in only slight or no alteration; therefore these effects do not themselves follow the rules of dosage compensation. Longer duplications in females have reductions of greater magnitude, but in some cases, the effect is less than the sum ofmore » the inclusive regions. Certain deficiencies in females produce specific elevations of X- encoded and one autosomally specified enzyme (ADH), while others reduce levels. Although there are numerous dosage sensitive regions altering the level of any one enzyme, Lucchesi and Rawls (1973) showed a positive correlation between enzyme level/cell and ploidy. The relationship of these observations to genetic balance phenomena found in higher eukaryotes will be discussed.« less
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Claims 4
Claim · model-written summary
Certain maize enzyme and protein levels were negatively correlated with segmental aneuploid dosage.
- Material
- segmental aneuploidse0
- Outcome
- enzyme and protein levelse0
- Direction
- negativelye0
- Qualifier
- 1-2-3 dosese0
Zea maysOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In maize, certain enzyme and protein levels have been found to be negatively correlated with several segmental aneuploids (1-2-3 doses)”
Claim · model-written summary
Fewer maize enzyme levels showed positive correlations with chromosome dosage.
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In fewer cases, positive correlations with chromosome dosage are observed.”
e1“In maize”
Claim · model-written summary
Alcohol and glutamate dehydrogenases and one protein were compensated across the dosage series.
- Material
- dosage seriese0
- Gene
- alcohol and glutamate dehydrogenasese0
- Outcome
- levels of alcohol and glutamate dehydrogenases and one protein speciese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The levels of alcohol and glutamate dehydrogenases and one protein species, all with structural genes in IL, are compensated in a dosage series”
e1“In maize”
Claim · model-written summary
ADH compensation appeared to involve cancellation of an inverse effect by gene dosage in scutellar tissue.
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“at least in the case of ADH, this appears to be due to a cancellation of an inverse effect by a gene dosage effect in scutellar tissue.”
e1“In maize”