Abstract
The COP9 Signalosome (CSN) is an evolutionarily conserved multi-protein complex that regulates proteasome-mediated proteolysis. While the CSN has been shown to function in various growth and developmental processes, the involvement of the CSN in the regulation of defense responses is largely unknown. It was shown that silencing of the CSN subunit CSN5 resulted in reduced wound-and herbivory-induced levels of jasmonic acid and reduced expression of wound-response genes. Unexpectedly, these plants also showed increased pathogenesis-related gene expression. Consequently, CSN5–silenced plants were more susceptible to feeding by herbivorous insects and infection by a necrotrophic fungus. It has been shown previously in our lab that a MAP kinase signaling cascade is an essential part of systemin-mediated defense signaling and functions upstream of jasmonic acid biosynthesis. Co-silencing of MPK1/2 and CSN5 had a synergistic effect on pathogenesis-related gene expression, suggesting that they function in the same signaling network. Together these finding suggest a role for the CSN in regulating jasmonic acid-dependent plant defense responses.
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Claims 7
Claim · model-written summary
CSN5 silencing reduced wound- and herbivory-induced jasmonic acid levels.
- Taxon
- tomato
Solanum lycopersicumt0 - Treatment
- silencing of the CSN subunit CSN5e0
- Gene
- CSN5e0
- Outcome
- wound-and herbivory-induced levels of jasmonic acide0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“silencing of the CSN subunit CSN5 resulted in reduced wound-and herbivory-induced levels of jasmonic acid”
Claim · model-written summary
CSN5 silencing reduced expression of wound-response genes.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- silencing of the CSN subunit CSN5e0
- Gene
- CSN5e0
- Outcome
- expression of wound-response genese0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“silencing of the CSN subunit CSN5 resulted in reduced wound-and herbivory-induced levels of jasmonic acid and reduced expression of wound-response genes”
Claim · model-written summary
CSN5-silenced plants had increased pathogenesis-related gene expression.
- Taxon
- tomatoSolanum lycopersicumt0
- Outcome
- pathogenesis-related gene expressione0
- Direction
- increasede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“these plants also showed increased pathogenesis-related gene expression”
Claim · model-written summary
CSN5-silenced plants were more susceptible to feeding by herbivorous insects.
- Taxon
- tomatoSolanum lycopersicumt0
- Material
- CSN5–silenced plantse0
- Interactor
- herbivorous insectse0herbivore
- Outcome
- susceptible to feeding by herbivorous insectse0
- Direction
- more susceptiblee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“CSN5–silenced plants were more susceptible to feeding by herbivorous insects”
Claim · model-written summary
CSN5-silenced plants were more susceptible to infection by a necrotrophic fungus.
- Taxon
- tomatoSolanum lycopersicumt0
- Material
- CSN5–silenced plantse0
- Interactor
- a necrotrophic funguse0pathogen
- Outcome
- infection by a necrotrophic funguse0
- Direction
- more susceptiblee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“CSN5–silenced plants were more susceptible to feeding by herbivorous insects and infection by a necrotrophic fungus”
Claim · model-written summary
Co-silencing MPK1/2 and CSN5 synergistically affected pathogenesis-related gene expression.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- Co-silencing of MPK1/2 and CSN5e0
- Gene
- MPK1/2 and CSN5e0
- Outcome
- pathogenesis-related gene expressione0
- Qualifier
- synergistic effecte0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Co-silencing of MPK1/2 and CSN5 had a synergistic effect on pathogenesis-related gene expression”
Claim · model-written summary
The authors suggest that CSN regulates jasmonic acid-dependent plant defense responses.
- Taxon
- tomatoSolanum lycopersicumt0
- Gene
- CSNe0
- Outcome
- jasmonic acid-dependent plant defense responsese0
- Qualifier
- suggest a rolee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Together these finding suggest a role for the CSN in regulating jasmonic acid-dependent plant defense responses”
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