Abstract
Investigation of the inhibitory fraction of Leucas aspera on prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A (1) and B (2) and leucasperols A (3) and B (4), and three new isopimarane glycosides, leucasperosides A, B, and C (5-7), together with the known compounds asperphenamate, maslinic acid, (-)-isololiolide, and linifolioside. The structures of the compounds were determined by detailed spectroscopic analysis. The configurations of 1 and 2 and the acetylated derivatives of 3 and 4 were determined by differential NOE analysis and CD data. Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions.
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Claims 10
Claim · model-written summary
New leucasperones A and B were isolated from Leucas aspera.
- Taxon
- Leucas aspera
Leucas asperae0 - Outcome
- leucasperones A (1) and B (2)e0
- Qualifier
- new diterpenese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Investigation of the inhibitory fraction of Leucas aspera on prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A (1) and B (2) and leucasperols A (3) and B (4)”
Claim · model-written summary
New leucasperols A and B were isolated from Leucas aspera.
- Taxon
- Leucas asperaLeucas asperae0
- Outcome
- leucasperols A (3) and B (4)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Leucas aspera on prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A (1) and B (2) and leucasperols A (3) and B (4)”
Claim · model-written summary
Three new leucasperoside glycosides were isolated.
- Taxon
- Leucas asperaLeucas asperat0
- Outcome
- leucasperosides A, B, and C (5-7)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“three new isopimarane glycosides, leucasperosides A, B, and C (5-7)”
t0“Leucas aspera”
Claim · model-written summary
Asperphenamate, maslinic acid and (-)-isololiolide were isolated.
- Taxon
- Leucas asperaLeucas asperat0
- Outcome
- asperphenamate, maslinic acid, (-)-isololiolidee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the known compounds asperphenamate, maslinic acid, (-)-isololiolide, and linifolioside”
t0“Leucas aspera”
Claim · model-written summary
Linifolioside was isolated.
- Taxon
- Leucas asperaLeucas asperat0
- Outcome
- linifoliosidee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the known compounds asperphenamate, maslinic acid, (-)-isololiolide, and linifolioside”
t0“Leucas aspera”
Claim · model-written summary
Compound structures and configurations were determined spectroscopically.
- Taxon
- Leucas asperaLeucas asperat0
- Outcome
- structures of the compoundse0
- Qualifier
- configurations of 1 and 2 and the acetylated derivatives of 3 and 4e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The structures of the compounds were determined by detailed spectroscopic analysis. The configurations of 1 and 2 and the acetylated derivatives of 3 and 4 were determined by differential NOE analysis and CD data.”
t0“Leucas aspera”
Claim · model-written summary
Leucasperone A inhibited prostaglandin-induced contractions.
- Taxon
- guinea pig
Cavia porcelluse1 - Treatment
- Leucasperone Ae0
- Outcome
- inhibition of prostaglandin-induced contractionse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
e1“guinea pig ileum”
Claim · model-written summary
Leucasperoside A inhibited prostaglandin-induced contractions.
- Taxon
- guinea pigCavia porcelluse1
- Treatment
- leucasperosides Ae0
- Outcome
- inhibition of prostaglandin-induced contractionse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
e1“guinea pig ileum”
Claim · model-written summary
Leucasperoside B inhibited prostaglandin-induced contractions.
- Taxon
- guinea pigCavia porcelluse1
- Treatment
- Be0
- Outcome
- inhibition of prostaglandin-induced contractionse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
e1“guinea pig ileum”
Claim · model-written summary
Linifolioside inhibited prostaglandin-induced contractions.
- Taxon
- guinea pigCavia porcelluse1
- Treatment
- linifoliosidee0
- Outcome
- inhibition of prostaglandin-induced contractionse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions”
e1“guinea pig ileum”