Abstract
SUMMARY Age-related resistance (ARR) occurs in numerous plant species, often resulting in increased disease resistance as plants mature. ARR in Arabidopsis to Pseudomonas syringae pv. tomato is associated with intercellular salicylic acid (SA) accumulation and the transition to flowering. Forward and reverse genetic screens were performed to identify genes required for ARR and to investigate the mechanism of the ARR response. Infiltration of SA into the intercellular space of the ARR-defective mutant iap1-1 (important for the ARR pathway) partially restored ARR function. Inter- and intracellular SA accumulation was reduced in the mutant iap1-1 compared with the wild-type, and the SA regulatory gene EDS1 was also required for ARR. Combining microarray analysis with reverse genetics using T-DNA insertion lines, four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)], a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)] and a cytidine deaminase [CDA1 (At2g19570)]. These four genes and IAP1 are also required for ARR to Hyaloperonospora parasitica. IAP1 encodes a key component of ARR that acts upstream of SA accumulation and possibly downstream of UGT85A1, CDA1 and the two NAC transcription factors (ANAC055, ANAC092).
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Claims 8
Claim · model-written summary
Intercellular SA infiltration partially restored ARR in iap1-1.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Material
- iap1-1e0
- Treatment
- Infiltration of SA into the intercellular spacee0
- Outcome
- ARR functione0
- Direction
- partially restorede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Infiltration of SA into the intercellular space of the ARR-defective mutant iap1-1 (important for the ARR pathway) partially restored ARR function”
t0“Arabidopsis thaliana”
Claim · model-written summary
Intercellular and intracellular SA accumulation fell in iap1-1.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- iap1-1e0
- Outcome
- Inter- and intracellular SA accumulatione0
- Direction
- reducede0
- Comparator
- wild-typee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Inter- and intracellular SA accumulation was reduced in the mutant iap1-1 compared with the wild-type”
t0“Arabidopsis thaliana”
Claim · model-written summary
EDS1 was required for ARR.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- EDS1e0
- Outcome
- required for ARRe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the SA regulatory gene EDS1 was also required for ARR”
t0“Arabidopsis thaliana”
Claim · model-written summary
ANAC055 and ANAC092 contributed to ARR.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- ANAC055 (At3g15500) and ANAC092 (At5g39610)e0
- Outcome
- contributing to ARRe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)]”
t0“Arabidopsis thaliana”
Claim · model-written summary
UGT85A1 contributed to ARR.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- UGT85A1 (At1g22400)e0
- Outcome
- contributing to ARRe1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)]”
e1“four additional ARR genes were identified as contributing to ARR”
t0“Arabidopsis thaliana”
Claim · model-written summary
CDA1 contributed to ARR.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- CDA1 (At2g19570)e0
- Outcome
- contributing to ARRe1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“a cytidine deaminase [CDA1 (At2g19570)]”
e1“four additional ARR genes were identified as contributing to ARR”
t0“Arabidopsis thaliana”
Claim · model-written summary
The four additional genes and IAP1 were required for resistance to H. parasitica.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Interactor
- Hyaloperonospora parasitica
Hyaloperonospora parasiticae0pathogen - Gene
- IAP1e0
- Outcome
- ARR to Hyaloperonospora parasiticae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“These four genes and IAP1 are also required for ARR to Hyaloperonospora parasitica”
t0“Arabidopsis thaliana”
Claim · model-written summary
IAP1 acts upstream of SA accumulation and possibly downstream of the other four genes.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- IAP1e0
- Outcome
- ARRe0
- Qualifier
- acts upstream of SA accumulation and possibly downstream of UGT85A1, CDA1 and the two NAC transcription factors (ANAC055, ANAC092)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“IAP1 encodes a key component of ARR that acts upstream of SA accumulation and possibly downstream of UGT85A1, CDA1 and the two NAC transcription factors (ANAC055, ANAC092)”
t0“Arabidopsis thaliana”
The same questions in other papers
salicylic acid · disease · Arabidopsis thaliana (thale cress)Positive and negative results
10 papers in the same direction as this paper · 5 in the opposite direction
- no effect
- negative
- negative
12 papers more in this group
See all 16 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.