Abstract
Acetylcholinesterase (AChE) inhibition-directed phytochemical studies on the methanolic extract of Buxus natalensis, collected in South Africa, resulted in the isolation of 12 compounds: O(2)-natafuranamine (1), O(10)-natafuranamine (2), cyclonataminol (3), 31-demethylbuxaminol A (4), buxaminol A (5), buxafuranamide (6), buxalongifolamidine (7), buxamine A (8), cyclobuxophylline K (9), buxaminol C (10), methyl syringate (11), and p-coumaroylputrescine (12). Compounds 1-4 were new alkaloids, and compound 5 was isolated for the first time as a natural product. Their structures were elucidated with the aid of extensive NMR and mass spectroscopic studies. Compounds 1 and 2 are members of a rarely occurring class of Buxus alkaloids, having a tetrahydrofuran ring incorporated in their structures. Compounds 1-12 exhibited strong to moderate AChE inhibitory activity.
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Claims 5
Claim · model-written summary
Phytochemical study of the Buxus natalensis extract yielded 12 compounds.
- Taxon
- Buxus natalensis
Buxus natalensise0 - Outcome
- isolatione1
- Value
- 12 compoundse1
- Setting
- South Africae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“methanolic extract of Buxus natalensis, collected in South Africa”
e1“resulted in the isolation of 12 compounds”
Claim · model-written summary
Compounds 1-4 from Buxus natalensis were new alkaloids.
- Taxon
- Buxus natalensisBuxus natalensise0
- Outcome
- new alkaloidse2
- Setting
- South Africae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“methanolic extract of Buxus natalensis, collected in South Africa”
e2“Compounds 1-4 were new alkaloids”
Claim · model-written summary
Compound 5 from Buxus natalensis was isolated for the first time as a natural product.
- Taxon
- Buxus natalensisBuxus natalensise0
- Outcome
- isolated for the first time as a natural producte3
- Setting
- South Africae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“methanolic extract of Buxus natalensis, collected in South Africa”
e3“compound 5 was isolated for the first time as a natural product”
Claim · model-written summary
Compounds 1 and 2 belong to a rarely occurring class of Buxus alkaloids with a tetrahydrofuran ring.
- Taxon
- Buxus natalensisBuxus natalensise0
- Outcome
- members of a rarely occurring class of Buxus alkaloidse4
- Setting
- South Africae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“methanolic extract of Buxus natalensis, collected in South Africa”
e4“Compounds 1 and 2 are members of a rarely occurring class of Buxus alkaloids, having a tetrahydrofuran ring incorporated in their structures”
Claim · model-written summary
Compounds 1-12 from Buxus natalensis showed strong to moderate acetylcholinesterase inhibitory activity.
- Taxon
- Buxus natalensisBuxus natalensise0
- Outcome
- AChE inhibitory activitye5
- Value
- strong to moderatee5
- Setting
- South Africae0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“methanolic extract of Buxus natalensis, collected in South Africa”
e5“Compounds 1-12 exhibited strong to moderate AChE inhibitory activity”