Abstract
Globularia aphyllanthes (Plantaginaceae) is a perennial plant, distributed from northwest Turkey to central and southern Europe [1]. Some members of the genus Globularia are used as hypoglycaemic, laxative, cholagogue and for the treatment of haemorrhoids in the folk medicines of some Mediterranean countries [2,3]. It has only been investigated for its iridoid contents so far [4]. In the continuation of our work on secondary metabolites of the genus Globularia from Turkey, we have isolated a new flavone glycoside, 6-hydroxyluteolin 7-O-[6'''-benzoyl-β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside (1) from the MeOH extract of the aerial parts of G. aphyllanthes. Besides this new compound, a flavonol glycoside, isoquercitrin, three phenylethanoid glycosides (verbascoside, rossicaside A, and trichosanthoside A), and seven iridoid glycosides (catalpol, globularin, asperuloside, besperuloside, asperulosidic acid, scandoside, and baldaccioside) were also obtained and characterized. Identification of the isolated compounds was carried out by spectroscopic analysis including 1D and 2D NMR experiments as well as HR-MS. The chlorinated iridoid glycoside, baldaccioside, was isolated for the first time from the genus Globularia, while its C-7 epimer was reported from G. alypum [5].
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Claims 4
Claim · model-written summary
A new flavone glycoside was isolated from aerial parts of G. aphyllanthes.
Verbatim
e0“we have isolated a new flavone glycoside, 6-hydroxyluteolin 7-O-[6'''-benzoyl-β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside (1) from the MeOH extract of the aerial parts of G. aphyllanthes”
Claim · model-written summary
Isoquercitrin and three phenylethanoid glycosides were obtained.
Verbatim
e0“a flavonol glycoside, isoquercitrin, three phenylethanoid glycosides (verbascoside, rossicaside A, and trichosanthoside A)”
t0“Globularia aphyllanthes”
Claim · model-written summary
Seven iridoid glycosides were obtained and characterized.
Verbatim
e0“seven iridoid glycosides (catalpol, globularin, asperuloside, besperuloside, asperulosidic acid, scandoside, and baldaccioside) were also obtained and characterized”
t0“Globularia aphyllanthes”
Claim · model-written summary
Baldaccioside was isolated from Globularia for the first time.
- Taxon
- Globularia
Globulariae0 - Outcome
- baldacciosidee0
- Qualifier
- for the first timee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“baldaccioside, was isolated for the first time from the genus Globularia”