Abstract
The Abnormal chromosome 10 (Ab10) in maize causes normally-quiescent blocks of heterochromatin called knobs to function as meiotic centromeres. Under these circumstances genetic markers associated with knobs exhibit meiotic drive, i.e., they are preferentially transmitted to progeny. Here we describe a mutation called suppressor of meiotic drive (smd1) that partially suppresses meiotic drive, and demonstrate that smd1 causes a quantitative reduction in the mobility of knobs on the meiotic spindle. We conclude that Smd1 encodes a product that is necessary for the activation of ectopic centromeres, and that meiotic drive occurs as a consequence of the resulting change in chromosome movement. As a genetic system, Ab10 offers a new and powerful approach for analyzing centromere/kinetochore function.
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Claims 4
Claim · model-written summary
smd1 partially suppresses meiotic drive in maize.
- Treatment
- a mutation called suppressor of meiotic drive (smd1)e2
- Gene
- smd1e2
- Outcome
- meiotic drivee2
- Direction
- partially suppressese2
Zea maysNot reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“centromeric activity in maize”
e2“Here we describe a mutation called suppressor of meiotic drive (smd1) that partially suppresses meiotic drive”
Claim · model-written summary
smd1 causes a quantitative reduction in the mobility of knobs on the meiotic spindle in maize.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“centromeric activity in maize”
e3“smd1 causes a quantitative reduction in the mobility of knobs on the meiotic spindle”
Claim · model-written summary
Smd1 encodes a product necessary for the activation of ectopic centromeres in maize.
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“centromeric activity in maize”
e4“We conclude that Smd1 encodes a product that is necessary for the activation of ectopic centromeres”
Claim · model-written summary
Meiotic drive in maize occurs as a consequence of the resulting change in chromosome movement.
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“centromeric activity in maize”
e5“meiotic drive occurs as a consequence of the resulting change in chromosome movement”