Paper · 1949 · The American Naturalist

Spontaneous Mutation at the R Locus in Maize. III. Genetic Modification of Mutation Rate

L. J. Stadler

10
claims
25
verbatim quotes
6
citations
1
research areas
—
Not open access

Abstract

1. The frequency of seed-color mutation of Rr: Cornell, which occurs at the rate of 18.2 x 10-4 in the Cornell stock, was reduced to 0 in the F1 of a cross with a multiple linkage tester stock. The number of Rr:Cornell gametes tested for mutation in the F1 was sufficient to have yielded 22 mutations at the rate characteristic of the Cornell stock. 2. The backcross, F1 x Cornell stock, yielded 30 mutations (rate 9.2 x 10-4). The incidence of these mutations in relation to the segregation for the various marker genes indicates the presence of dominant genes favoring seed-color mutation of Rr:Cornell in the Y-marked segment and the J-marked segment of the tester stock. Similarly, the Rg-marked segment shows an effect unfavorable to the occurrence of the mutation. 3. The increase in mutation rate associated with the presence of the J segment appears to be highly significant statistically (P < .01). Since the statistical comparison assumes that sampling error due to individual plant variability is negligible, and since the results of the experiment as a whole indicate that plant variability may be very great, the evidence for the occurrence of this modifier is not considered conclusive. 4. The increase in mutation rate associated with the Y-segment was not quite significant in the backcross generation, but was clearly confirmed in the self-progeny of a backcross plant. The ratio of mutation rate in the y y vs. the Y y class was 1.0:2.3 in the backcross generation and 1.0:3.5 in the following generation. 5. The decrease in mutation rate associated with the Rg segment was significant in the backcross generation (P < .05) and was supported, in numbers inadequate for significance, in the second backcross generation. The location of a modifier in this segment is supported also by significant evidence of the same sort from a cross of Cornell with another stock. The ratio of mutation rate in the Rr Rr vs. the Rr Rg class was 3.5:1.0 in the backcross generation of the cross with the linkage tester stock, and 4.4:1.0 in the backcross generation of the other cross mentioned. 6. The effect of the modifiers upon mutation frequency appears to be cumulative, so far as may be judged from the limited data.

Abstract from the paper’s OpenAlex record, shown for indexing and research. Copyright remains with the authors or the publisher. Read at the source ↗

The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.

Claims 10

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

The seed-color mutation frequency of Rr: Cornell, 18.2 x 10-4 in the Cornell stock, was reduced to 0 in the F1 of a cross with a multiple linkage tester stock.

Taxon
MaizeZea mayst0
Treatment
cross with a multiple linkage tester stocke0
Outcome
frequency of seed-color mutation of Rr: Cornelle0
Direction
reducede0
Value
0e0
Qualifier
18.2 x 10-4 in the Cornell stocke0
Comparator
Cornell stocke0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The frequency of seed-color mutation of Rr: Cornell, which occurs at the rate of 18.2 x 10-4 in the Cornell stock, was reduced to 0 in the F1 of a cross with a multiple linkage tester stock”

✓ located verbatim in the source · abstract, characters 3–192 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

The backcross of F1 to the Cornell stock yielded 30 mutations at a rate of 9.2 x 10-4.

Taxon
MaizeZea mayst0
Outcome
mutationse0
Value
9.2 x 10-4e0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The backcross, F1 x Cornell stock, yielded 30 mutations (rate 9.2 x 10-4)”

✓ located verbatim in the source · abstract, characters 353–426 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Mechanismauthor interpretationoriginal resultmeasured

Claim · model-written summary

Mutation incidence in relation to marker segregation indicates dominant genes favoring seed-color mutation of Rr:Cornell in the Y-marked and J-marked segments of the tester stock.

Taxon
MaizeZea mayst0
Gene
dominant genese0
Outcome
seed-color mutation of Rr:Cornelle0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“indicates the presence of dominant genes favoring seed-color mutation of Rr:Cornell in the Y-marked segment and the J-marked segment of the tester stock”

✓ located verbatim in the source · abstract, characters 521–673 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationauthor interpretationoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

The increase in mutation rate associated with the J segment appears highly significant (P < .01), but the authors do not consider the evidence for this modifier conclusive.

Taxon
MaizeZea mayst0
Gene
J segmente0
Outcome
mutation ratee0
Direction
increasee0
Qualifier
the evidence for the occurrence of this modifier is not considered conclusivee1

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The increase in mutation rate associated with the presence of the J segment appears to be highly significant statistically (P < .01)”

✓ located verbatim in the source · abstract, characters 774–906 · show in text ↑
e1

“the evidence for the occurrence of this modifier is not considered conclusive”

✓ located verbatim in the source · abstract, characters 1122–1199 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationobservedoriginal resultpositivenot significant (as stated)measured

Claim · model-written summary

The increase in mutation rate associated with the Y-segment was not quite significant in the backcross generation, where the ratio of mutation rate y y vs. Y y was 1.0:2.3.

Taxon
MaizeZea mayst0
Gene
Y-segmente0
Outcome
mutation ratee0
Direction
increasee0
Value
1.0:2.3e1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The increase in mutation rate associated with the Y-segment was not quite significant in the backcross generation”

✓ located verbatim in the source · abstract, characters 1204–1317 · show in text ↑
e1

“The ratio of mutation rate in the y y vs. the Y y class was 1.0:2.3 in the backcross generation and 1.0:3.5 in the following generation”

✓ located verbatim in the source · abstract, characters 1387–1522 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationobservedoriginal resultpositivemeasured

Claim · model-written summary

The increase in mutation rate associated with the Y-segment was clearly confirmed in the self-progeny of a backcross plant, with a y y vs. Y y ratio of 1.0:3.5 in the following generation.

Taxon
MaizeZea mayst0
Gene
Y-segmente0
Outcome
mutation ratee0
Direction
increasee0
Value
1.0:3.5e1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The increase in mutation rate associated with the Y-segment was not quite significant in the backcross generation, but was clearly confirmed in the self-progeny of a backcross plant”

✓ located verbatim in the source · abstract, characters 1204–1385 · show in text ↑
e1

“The ratio of mutation rate in the y y vs. the Y y class was 1.0:2.3 in the backcross generation and 1.0:3.5 in the following generation”

✓ located verbatim in the source · abstract, characters 1387–1522 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationobservedoriginal resultnegativesignificant (as stated)measured

Claim · model-written summary

The decrease in mutation rate associated with the Rg segment was significant in the backcross generation (P < .05), with a mutation rate ratio Rr Rr vs. Rr Rg of 3.5:1.0 in the cross with the linkage tester stock.

Taxon
MaizeZea mayst0
Gene
Rg segmente0
Outcome
mutation ratee0
Direction
decreasee0
Value
3.5:1.0e1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The decrease in mutation rate associated with the Rg segment was significant in the backcross generation (P < .05)”

✓ located verbatim in the source · abstract, characters 1527–1641 · show in text ↑
e1

“The ratio of mutation rate in the Rr Rr vs. the Rr Rg class was 3.5:1.0 in the backcross generation of the cross with the linkage tester stock”

✓ located verbatim in the source · abstract, characters 1883–2025 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationobservedoriginal resultnegativesignificant (as stated)measured

Claim · model-written summary

Significant evidence from a cross of Cornell with another stock supported a modifier in the Rg segment, with a mutation rate ratio of 4.4:1.0 in the backcross generation of that cross.

Taxon
MaizeZea mayst0
Gene
modifiere0
Outcome
modifier in this segmente0
Value
4.4:1.0e1

Not reportedComparatorDirection

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The location of a modifier in this segment is supported also by significant evidence of the same sort from a cross of Cornell with another stock”

✓ located verbatim in the source · abstract, characters 1737–1881 · show in text ↑
e1

“4.4:1.0 in the backcross generation of the other cross mentioned”

✓ located verbatim in the source · abstract, characters 2031–2095 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Associationobservedoriginal resultnegativenot significant (as stated)measured

Claim · model-written summary

The decrease in mutation rate associated with the Rg segment was supported, in numbers inadequate for significance, in the second backcross generation.

Taxon
MaizeZea mayst0
Gene
Rg segmente0
Outcome
mutation ratee0
Direction
decreasee0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The decrease in mutation rate associated with the Rg segment was significant in the backcross generation (P < .05) and was supported, in numbers inadequate for significance, in the second backcross generation”

✓ located verbatim in the source · abstract, characters 1527–1735 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑
Observationauthor interpretationoriginal resultmeasured

Claim · model-written summary

The effect of the modifiers upon mutation frequency appears to be cumulative, judged from limited data.

Taxon
MaizeZea mayst0
Outcome
effect of the modifiers upon mutation frequencye0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“The effect of the modifiers upon mutation frequency appears to be cumulative”

✓ located verbatim in the source · abstract, characters 2100–2176 · show in text ↑
t0

“Maize”

✓ located verbatim in the source · title, characters 39–44 · show in text ↑