Abstract
Programmed cell death (PCD) is the main defense mechanism in plants to fight various pathogens including viruses. The best-studied example of virus-induced PCD in plants is Tobacco mosaic virus (TMV)-elicited hypersensitive response in tobacco plants containing the N resistance gene. It was previously reported that the animal mitochondrial protein Bcl-xL, which lacks a homolog in plants, effectively suppresses plant PCD induced by TMV p50 - the elicitor of hypersensitive response in Nicotiana tabacum carrying the N gene. Our studies show that the mitochondria-targeted antioxidant SkQ1 effectively suppresses p50-induced PCD in tobacco plants. On the other hand, SkQ1 did not affect Poa semilatent virus TGB3-induced endoplasmic reticulum stress, which is followed by PCD, in Nicotiana benthamiana epidermal cells. These data suggest that mitochondria-targeted antioxidant SkQ1 can be used to study molecular mechanisms of PCD suppression in plants.
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Claims 3
Claim · model-written summary
SkQ1 suppressed p50-induced programmed cell death in tobacco.
- Taxon
- tobacco plants
Nicotiana tabacume0 - Treatment
- SkQ1e0
- Outcome
- p50-induced PCDe0
- Direction
- suppressese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the mitochondria-targeted antioxidant SkQ1 effectively suppresses p50-induced PCD in tobacco plants.”
t0“viral proteins”
Claim · model-written summary
SkQ1 did not affect TGB3-induced endoplasmic reticulum stress in Nicotiana benthamiana.
- Taxon
- Nicotiana benthamiana
Nicotiana benthamianae0 - Organ / stage
- epidermal cellse0
- Treatment
- SkQ1e0
- Interactor
- Poa semilatent virusPoa semilatent viruse0pathogen
- Outcome
- Poa semilatent virus TGB3-induced endoplasmic reticulum stresse0
- Direction
- did not affecte0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SkQ1 did not affect Poa semilatent virus TGB3-induced endoplasmic reticulum stress, which is followed by PCD, in Nicotiana benthamiana epidermal cells.”
Claim · model-written summary
SkQ1 can be used to study mechanisms of plant PCD suppression.
- Taxon
- plantsViridiplantaee0
- Treatment
- SkQ1e0
- Outcome
- study molecular mechanisms of PCD suppressione0
Verbatim
e0“mitochondria-targeted antioxidant SkQ1 can be used to study molecular mechanisms of PCD suppression in plants.”