Abstract
Meiotic drive is the subversion of meiosis so that particular genes are preferentially transmitted to the progeny. Meiotic drive generally causes the preferential segregation of small regions of the genome; however, in maize we propose that meiotic drive is responsible for the evolution of large repetitive DNA arrays on all chromosomes. A maize meiotic drive locus found on an uncommon form of chromosome 10 [abnormal 10 (Ab10)] may be largely responsible for the evolution of heterochromatic chromosomal knobs, which can confer meiotic drive potential to every maize chromosome. Simulations were used to illustrate the dynamics of this meiotic drive model and suggest knobs might be deleterious in the absence of Ab10. Chromosomal knob data from maize's wild relatives (Zea mays ssp. parviglumis and mexicana) and phylogenetic comparisons demonstrated that the evolution of knob size, frequency, and chromosomal position agreed with the meiotic drive hypothesis. Knob chromosomal position was incompatible with the hypothesis that knob repetitive DNA is neutral or slightly deleterious to the genome. We also show that environmental factors and transposition may play a role in the evolution of knobs. Because knobs occur at multiple locations on all maize chromosomes, the combined effects of meiotic drive and genetic linkage may have reshaped genetic diversity throughout the maize genome in response to the presence of Ab10. Meiotic drive may be a major force of genome evolution, allowing revolutionary changes in genome structure and diversity over short evolutionary periods.
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Claims 7
Claim · model-written summary
Simulations suggested knobs may be deleterious without Ab10.
Zea maysNot reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Simulations were used to illustrate the dynamics of this meiotic drive model and suggest knobs might be deleterious in the absence of Ab10.”
t0“Maize”
Claim · model-written summary
Knob size, frequency and chromosome position agreed with the meiotic drive hypothesis.
- Outcome
- evolution of knob size, frequency, and chromosomal positione0
- Qualifier
- meiotic drive hypothesise0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the evolution of knob size, frequency, and chromosomal position agreed with the meiotic drive hypothesis.”
t0“Maize”
Claim · model-written summary
Knob positions were incompatible with neutral or slightly deleterious repetitive DNA.
- Outcome
- Knob chromosomal positione0
- Qualifier
- incompatible with the hypothesis that knob repetitive DNA is neutral or slightly deleterious to the genomee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Knob chromosomal position was incompatible with the hypothesis that knob repetitive DNA is neutral or slightly deleterious to the genome.”
t0“Maize”
Claim · model-written summary
Environmental factors may influence knob evolution.
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“environmental factors and transposition may play a role in the evolution of knobs.”
t0“Maize”
Claim · model-written summary
Transposition may influence knob evolution.
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“environmental factors and transposition may play a role in the evolution of knobs.”
t0“Maize”
Claim · model-written summary
Meiotic drive and linkage may have reshaped maize genetic diversity in response to Ab10.
- Gene
- Ab10e0
- Outcome
- genetic diversity throughout the maize genomee0
- Qualifier
- meiotic drive and genetic linkagee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the combined effects of meiotic drive and genetic linkage may have reshaped genetic diversity throughout the maize genome in response to the presence of Ab10.”
Claim · model-written summary
Authors propose meiotic drive can cause rapid genome structural and diversity change.
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Meiotic drive may be a major force of genome evolution, allowing revolutionary changes in genome structure and diversity over short evolutionary periods.”
t0“Maize”