Paper · 2005 · Complementary Medicine Research

A Biostatistical Insight into the As2O3 High Dilution Effects on the Rate and Variability of Wheat Seedling Growth

Maurizio Brizzi; Lisa Lazzarato; Daniele Nani; et al.

5
claims
10
verbatim quotes
41
citations
1
research areas
—
Not open access

Abstract

BACKGROUND: Most criticism of homeopathy concerns the lack of scientific bases and theoretical models. Fundamental research could make important contributions to our understanding of the mechanisms of action of homeopathic treatments. Plant-based bioassays are suitable for basic research -- lacking the placebo effect and ensuring large data samples for structured statistical analyses. OBJECTIVE: The aim of this study was to reproduce a previous experiment on the effects of arsenic trioxide (As(2)O(3)) high dilutions on wheat seedling growth in order to verify whether the same significant results could be obtained working in a different place and with a different experimental team. A further goal was to investigate high dilution effects on variability. MATERIAL AND METHODS: A structured experiment was performed blind over 9 weeks, using wheat seeds previously stressed with a sublethal dose of As(2)O(3). The seeds were then treated with either potentized As(2)O(3) (5x, 15x, 25x, 35x, 45x), potentized water (equivalent potencies) or diluted As(2)O(3) (10(-5), 10(-15), 10(-25), 10(-35), 10(-45)). The working variable was the stem length, measured after 4, 5, 6 and 7 days. RESULTS: Some potencies (As(2)O(3) 45x and H(2)O 45x) induced a relevant increase in seedling growth and/or a variability decrease. Diluted As(2)O(3) did not induce any significant results. CONCLUSIONS: Confirmation of a significant stimulating effect on seedling growth and a significant decrease of variability was obtained with ultra-high dilutions at the 45x potency. The model of wheat germination and growth has been confirmed to be a good tool for basic research in homeopathy.

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Claims 5

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

The As(2)O(3) 45x potency induced a relevant increase in wheat seedling growth.

Treatment
As(2)O(3) 45xe1
Outcome
seedling growthe1
Direction
increasee1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

t0

“Wheat Seedling Growth”

✓ located verbatim in the source · title, characters 93–114 · show in text ↑
e1

“Some potencies (As(2)O(3) 45x and H(2)O 45x) induced a relevant increase in seedling growth and/or a variability decrease”

✓ located verbatim in the source · abstract, characters 1196–1317 · show in text ↑
Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

The H(2)O 45x potency induced a relevant increase in wheat seedling growth.

Treatment
H(2)O 45xe1
Outcome
seedling growthe1
Direction
increasee1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

t0

“Wheat Seedling Growth”

✓ located verbatim in the source · title, characters 93–114 · show in text ↑
e1

“Some potencies (As(2)O(3) 45x and H(2)O 45x) induced a relevant increase in seedling growth and/or a variability decrease”

✓ located verbatim in the source · abstract, characters 1196–1317 · show in text ↑
Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

Ultra-high dilutions at the 45x potency significantly decreased the variability of wheat seedling growth.

Treatment
ultra-high dilutions at the 45x potencye3
Outcome
variabilitye3
Direction
decreasee3

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

t0

“Wheat Seedling Growth”

✓ located verbatim in the source · title, characters 93–114 · show in text ↑
e3

“Confirmation of a significant stimulating effect on seedling growth and a significant decrease of variability was obtained with ultra-high dilutions at the 45x potency”

✓ located verbatim in the source · abstract, characters 1390–1557 · show in text ↑
Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

Ultra-high dilutions at the 45x potency had a significant stimulating effect on wheat seedling growth.

Treatment
ultra-high dilutions at the 45x potencye3
Outcome
seedling growthe3
Direction
stimulating effecte3

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

t0

“Wheat Seedling Growth”

✓ located verbatim in the source · title, characters 93–114 · show in text ↑
e3

“Confirmation of a significant stimulating effect on seedling growth and a significant decrease of variability was obtained with ultra-high dilutions at the 45x potency”

✓ located verbatim in the source · abstract, characters 1390–1557 · show in text ↑
Intervention effectobservedoriginal resultno effectnot significant (as stated)measured

Claim · model-written summary

Diluted As(2)O(3) did not induce any significant result on wheat seedlings.

Treatment
Diluted As(2)O(3)e2
Outcome
significant resultse2
Direction
did not inducee2

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

t0

“Wheat Seedling Growth”

✓ located verbatim in the source · title, characters 93–114 · show in text ↑
e2

“Diluted As(2)O(3) did not induce any significant results”

✓ located verbatim in the source · abstract, characters 1319–1375 · show in text ↑

arsenic atom · growth · Triticum aestivum (wheat)Results differ

15 papers: 3 positive, 12 negative or no effect

2 papers in the same direction as this paper · 12 in the opposite direction

  1. no effect
  2. positive
  3. negative

11 papers more in this group

See all 15 papers →

ozone · growth · Triticum aestivum (wheat)Results differ

58 papers: 14 positive, 44 negative or no effect

13 papers in the same direction as this paper · 44 in the opposite direction

  1. negative
  2. negative
  3. negative

54 papers more in this group

See all 58 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.