Abstract
A plethora of diverse programmed cell death (PCD) processes has been described in living organisms. In animals and plants, different forms of PCD play crucial roles in development, immunity, and responses to the environment. While the molecular control of some animal PCD forms such as apoptosis is known in great detail, we still know comparatively little about the regulation of the diverse types of plant PCD. In part, this deficiency in molecular understanding is caused by the lack of reliable reporters to detect PCD processes. Here, we addressed this issue by using a combination of bioinformatics approaches to identify commonly regulated genes during diverse plant PCD processes in Arabidopsis (Arabidopsis thaliana). Our results indicate that the transcriptional signatures of developmentally controlled cell death are largely distinct from the ones associated with environmentally induced cell death. Moreover, different cases of developmental PCD share a set of cell death-associated genes. Most of these genes are evolutionary conserved within the green plant lineage, arguing for an evolutionary conserved core machinery of developmental PCD. Based on this information, we established an array of specific promoter-reporter lines for developmental PCD in Arabidopsis. These PCD indicators represent a powerful resource that can be used in addition to established morphological and biochemical methods to detect and analyze PCD processes in vivo and in planta.
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Claims 4
Claim · model-written summary
Developmental and environmental cell death had largely distinct transcriptional signatures.
- Taxon
- Arabidopsis
Arabidopsise7 - Outcome
- transcriptional signatures of developmentally controlled cell deathe0
- Comparator
- environmentally induced cell deathe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“transcriptional signatures of developmentally controlled cell death are largely distinct from the ones associated with environmentally induced cell death”
e7“Arabidopsis (Arabidopsis thaliana)”
Claim · model-written summary
Different developmental cell death cases shared a gene set.
- Taxon
- ArabidopsisArabidopsise7
- Outcome
- share a set of cell death-associated genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“different cases of developmental PCD share a set of cell death-associated genes”
e7“Arabidopsis (Arabidopsis thaliana)”
Claim · model-written summary
Most shared genes were conserved in the green plant lineage.
- Taxon
- ArabidopsisArabidopsise7
- Outcome
- evolutionary conserved within the green plant lineagee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Most of these genes are evolutionary conserved within the green plant lineage”
e7“Arabidopsis (Arabidopsis thaliana)”
Claim · model-written summary
An array of specific promoter reporter lines for developmental PCD was established.
- Taxon
- ArabidopsisArabidopsise0
- Outcome
- promoter-reporter lines for developmental PCDe0
- Value
- an arraye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“we established an array of specific promoter-reporter lines for developmental PCD in Arabidopsis”