Abstract
Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.
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Claims 5
Claim · model-written summary
A new oleanane-type triterenoid was isolated and identified from stem bark extract.
- Taxon
- Terminalia browniiTerminalia browniie0
- Organ / stage
- stem barke1
- Outcome
- identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1)e1
Verbatim
e0“Terminalia brownii”
e1“A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1)”
Claim · model-written summary
Seven known oleanane-type triterpenoids were identified with the new constituent.
- Taxon
- Terminalia browniiTerminalia browniie0
- Outcome
- seven known oleanane-type triterpenoidse1
Not reportedValue
Verbatim
e0“Terminalia brownii”
e1“along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives”
Claim · model-written summary
Seven ellagic acid derivatives were identified with the new constituent.
- Taxon
- Terminalia browniiTerminalia browniie0
- Outcome
- seven ellagic acid derivativese1
Verbatim
e0“Terminalia brownii”
e1“seven ellagic acid derivatives”
Claim · model-written summary
23-galloylarjunolic acid had the most potent antiplasmodial activity against P. falciparum W2, with IC50 of 2.76 µg/mL.
- Taxon
- Terminalia browniiTerminalia browniie0
- Outcome
- antiplasmodial activitye1
- Direction
- most potente1
- Value
- 2.76 µg/mLe1
- Qualifier
- 23-galloylarjunolic acid (2) against P. falciparum W2 straine1
Not reportedMaterial
Verbatim
e0“Terminalia brownii”
e1“most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain”
Claim · model-written summary
Diellagic lactone had the most potent antimicrobial activity against C. glabrata, with IC50 of 0.32 µg/mL.
Verbatim
e0“Terminalia brownii”
e1“most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata”