Abstract
The use of medicinal plants is an ancient practice, in part due to the evidenced richness in phytotherapeutic properties [l]. Currently, a wide variety of studies have been carried out, towards the investigation of these natural matrices, clarifying effects, health benefits and even mechanism of action of some of their bioactive compounds, namely phenolic compounds [2,3]. In parallel with these advances, an increasing incidence of opportunistic fungal infections has been observed, associated with development of antimicrobial drugs-resistant by the microorganisms [ 4]. In this sense, alternatives to the current antifungal drugs are necessary. In this work, the antifungal potential of Rubus ulmifolius Schott (Rosaceae) methanol! water (80:20, v!v) extract, prepared from flower buds, was evaluated against nineteen Candida strains, belonging to the species C. albicans, C. glabrata, C. parapsilosis and C. tropicalis, by using the disc diffusion halo assay. The obtained results were expressed as inhibition zones (mm). R. ulmifolius extract was effective against eleven Candida strains, maintaining the inhibitory effect at 24h, 48h and even 72h. At the tested concentration (SO mg/mL), the inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata (16-19 mm) and 9-10 mm for C. parapsilosis. Regarding C. tropicalis, only impairment on the cellular growth was observed. The most abundant compounds found in the extract were ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin C. Besides ellagitannins, flavonoids such as quercetin and kaempferol based flavonol conjugates were also found, being quercetin 3-0-glucuronide and quercetin 3-0-glucoside the most abundant [5].
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Claims 7
Claim · model-written summary
Rubus ulmifolius extract inhibited eleven Candida strains through 72 hours.
- Taxon
- R. ulmifolius
Rubus ulmifoliuse0 - Outcome
- inhibitory effecte0
- Value
- eleven Candida strainse0
- Qualifier
- 24h, 48h and even 72he0
CandidaOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“R. ulmifolius extract was effective against eleven Candida strains, maintaining the inhibitory effect at 24h, 48h and even 72h”
Claim · model-written summary
Candida albicans inhibition zones ranged from 9 to 15 mm.
- Taxon
- C. albicans
Candida albicanse0 - Outcome
- inhibition zonese0
- Direction
- rangede0
- Value
- 9-15 mme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“inhibition zones ranged between 9-15 mm for C. albicans”
Claim · model-written summary
Candida glabrata inhibition zones ranged from 16 to 19 mm.
- Taxon
- C. glabrata
Nakaseomyces glabratuse0 - Outcome
- inhibition zonese0
- Direction
- rangede0
- Value
- 16-19 mme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata”
Claim · model-written summary
Candida parapsilosis inhibition zones ranged from 9 to 10 mm.
Verbatim
e0“inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata (16-19 mm) and 9-10 mm for C. parapsilosis”
Claim · model-written summary
The extract impaired Candida tropicalis cellular growth.
- Taxon
- C. tropicalis
Candida tropicalise0 - Outcome
- cellular growthe0
- Direction
- impairmente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Regarding C. tropicalis, only impairment on the cellular growth was observed”
Claim · model-written summary
Ellagitannin derivatives including a sanguiin H -10 isomer and lambertianin C were the most abundant extract compounds.
- Taxon
- Rubus ulmifolius SchottRubus ulmifoliust0
- Outcome
- ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin Ce0
- Direction
- most abundante0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The most abundant compounds found in the extract were ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin C”
t0“Rubus ulmifolius Schott”
Claim · model-written summary
Quercetin 3-0-glucuronide and quercetin 3-0-glucoside were the most abundant flavonol conjugates.
- Taxon
- Rubus ulmifolius SchottRubus ulmifoliust0
- Outcome
- quercetin 3-0-glucuronide and quercetin 3-0-glucosidee0
- Direction
- most abundante0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“quercetin 3-0-glucuronide and quercetin 3-0-glucoside the most abundant”
t0“Rubus ulmifolius Schott”