Abstract
Grade evaluation method of quality constant is a kind of grading method for Chinese medicinal materials and decoction pieces,combining the external morphological index and internal content index. This method was used in this paper for grade evaluation of Gardeniae Fructus. By measuring the morphological and content indexes of 14 batches of Gardeniae Fructus,a method for calculating the quality constant of fruits was established,and the grade evaluation criteria were formed. At the same time,the NO inhibition effect of different grades of Gardeniae Fructus samples on RAW264. 7 cells induced by LPS was determined to investigate the relationship between the quality grade and pharmacodynamics of decoction pieces. The results showed that the quality constants of Gardeniae Fructus decoction piece samples ranged from 1. 46 to 4. 42. If the percentage quality constant ≥80% was classified into first-class,50%-80%as second-class and the rest as third-class,the quality constant was ≥3. 54 for first-class,2. 21-3. 54 for second-class and <2. 21 for third-class Gardeniae Fructus decoction pieces. The pharmacodynamic results showed that the pharmacodynamic intensity was positively correlated with the grade,which also proved the rationality of the grade evaluation method of quality constant.
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Claims 5
Claim · model-written summary
Quality constants of Gardeniae Fructus decoction piece samples ranged from 1.46 to 4.42.
Verbatim
e0“the quality constants of Gardeniae Fructus decoction piece samples ranged from 1. 46 to 4. 42”
Claim · model-written summary
Gardeniae Fructus decoction pieces with a quality constant of at least 3.54 were classed as first-class.
Verbatim
e0“the quality constants of Gardeniae Fructus decoction piece samples ranged from 1. 46 to 4. 42”
e1“the quality constant was ≥3. 54 for first-class,2. 21-3. 54 for second-class and <2. 21 for third-class”
Claim · model-written summary
Gardeniae Fructus decoction pieces with a quality constant of 2.21 to 3.54 were classed as second-class.
Verbatim
e0“the quality constants of Gardeniae Fructus decoction piece samples ranged from 1. 46 to 4. 42”
e1“the quality constant was ≥3. 54 for first-class,2. 21-3. 54 for second-class and <2. 21 for third-class”
Claim · model-written summary
Gardeniae Fructus decoction pieces with a quality constant below 2.21 were classed as third-class.
Verbatim
e0“the quality constants of Gardeniae Fructus decoction piece samples ranged from 1. 46 to 4. 42”
e1“the quality constant was ≥3. 54 for first-class,2. 21-3. 54 for second-class and <2. 21 for third-class”
Claim · model-written summary
Pharmacodynamic intensity of Gardeniae Fructus was positively correlated with its quality grade.
Verbatim
e2“the pharmacodynamic intensity was positively correlated with the grade”
e3“NO inhibition effect of different grades of Gardeniae Fructus samples on RAW264. 7 cells induced by LPS”