Paper · 2014 · China Journal of Chinese Materia Medica

Quantitative HPLC analysis of main effective constituents and integrated chemical quality index(ICQI)in Dida

Xiao-Quan Yang; Yong-Qiang Guo; Cong-Long Xia

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verbatim quotes
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citations
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research areas
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Not open access

Abstract

"Dida" is one of the most representative commonly used Tibetan medicines in treatment of hepatobilaiary diseases. To analyze and compare the content of 7 effective constituents in 11 species which are used as Dida. Integrated evaluation of them, which supply a basis for the resources exploitation for them. In this paper, most appropriate absorption wavelengths of different natural iridoid compounds, xanthones and oleanolic acid have been performed by using 3D spectrum technique. According to the results, the wavelength 210, 240 and 265 nm were used for detection of 7 effective constituents. By means of calculation, determination of 7 effective constituents indicated good linearity over the linear range with coefficients (r) of 0.999 9 respectively. The recoveries were found in the average range of 99% to 101% with RSD being less than 3%. Normalize and integrate by three-dimension the data. Get their integrated chemical quality index(ICQI). Results suggested that these plants used as Dida in Tibet medicine mostly contain these 7 effective constituents, but the different is notable. The integrated evaluation by the integrated chemical quality index (ICQI) has reference value for quality control.

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Claims 6

Method / resourceobservedoriginal resultmeasured

Claim · model-written summary

Detection of the seven constituents used 210, 240 and 265 nm wavelengths.

Outcome
detection of 7 effective constituentse0
Value
210, 240 and 265 nme0

Not reportedTaxon

Verbatim

e0

“the wavelength 210, 240 and 265 nm were used for detection of 7 effective constituents.”

✓ located verbatim in the source · abstract, characters 510–597 · show in text ↑
Method / resourceobservedoriginal resultmeasured

Claim · model-written summary

Determination of the seven constituents showed linearity with coefficients of 0.999 9.

Outcome
good linearitye0
Value
0.999 9e0

Verbatim

e0

“determination of 7 effective constituents indicated good linearity over the linear range with coefficients (r) of 0.999 9 respectively.”

✓ located verbatim in the source · abstract, characters 623–758 · show in text ↑
Method / resourceobservedoriginal resultmeasured

Claim · model-written summary

Average analytical recoveries were 99% to 101%.

Outcome
recoveriese0
Value
99% to 101%e0

Verbatim

e0

“The recoveries were found in the average range of 99% to 101% with RSD being less than 3%.”

✓ located verbatim in the source · abstract, characters 759–849 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Most Dida plants contained the seven effective constituents, with notable differences among them.

Taxon
plants used as Didae0
Outcome
contain these 7 effective constituentse0
Qualifier
the different is notablee0

Verbatim

e0

“these plants used as Dida in Tibet medicine mostly contain these 7 effective constituents, but the different is notable.”

✓ located verbatim in the source · abstract, characters 977–1097 · show in text ↑
Method / resourceauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

The authors considered the integrated chemical quality index useful for quality control.

Outcome
reference value for quality controle0
Comparator
integrated chemical quality index (ICQI)e0

Verbatim

e0

“The integrated evaluation by the integrated chemical quality index (ICQI) has reference value for quality control.”

✓ located verbatim in the source · abstract, characters 1098–1212 · show in text ↑