Abstract
Abstract BACKGROUND Herbicides acting on biosynthesis of plant pigments have contributed greatly to weed control in recent years. In our previous studies, 2‐methoxybenzamides were discovered as a novel type of lead compound for the development of bleaching herbicides. RESULTS A total of 67 benzamide analogues were synthesized and evaluated for herbicidal activity. The structure–activity relationship (SAR) revealed that a methoxyl substitution at the 2‐position of the benzoyl moiety is essential for the herbicidal activity of benzamide derivatives, and introduction of small substituents at the meta ‐ or para ‐position of the benzylamine moiety is also beneficial. Compounds 4 , 43 and 44 showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at an application rate of 150 g a.i. ha −1 . CONCLUSION The relationship between the structure and herbicidal activity of 2‐methoxybenzamides was discussed intensively. Compounds 4 , 43 and 44 may serve as novel candidates with a bleaching effect. © 2021 Society of Chemical Industry
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Claims 5
Claim · model-written summary
A 2-position methoxyl substitution was essential for herbicidal activity.
Not reportedTaxonDirection
Verbatim
e0“a methoxyl substitution at the 2‐position of the benzoyl moiety is essential for the herbicidal activity of benzamide derivatives”
Claim · model-written summary
Small meta or para substituents on the benzylamine moiety benefited herbicidal activity.
Not reportedTaxonDirection
Verbatim
e0“introduction of small substituents at the meta ‐ or para ‐position of the benzylamine moiety is also beneficial”
Claim · model-written summary
Compounds 4, 43 and 44 fully inhibited Abutilon theophrasti at the stated rate.
- Taxon
- Abutilon theophrasti
Abutilon theophrastie0 - Treatment
- Compounds 4 , 43 and 44e0
- Outcome
- inhibition against Abutilon theophrastie0
- Direction
- inhibitione0
- Value
- 100%e0
- Qualifier
- 150 g a.i. ha −1e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Compounds 4 , 43 and 44 showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at an application rate of 150 g a.i. ha −1”
Claim · model-written summary
Compounds 4, 43 and 44 fully inhibited Amaranthus retroflexus at the stated rate.
- Taxon
- Amaranthus retroflexus
Amaranthus retroflexuse0 - Treatment
- Compounds 4 , 43 and 44e0
- Outcome
- inhibition against Abutilon theophrasti and Amaranthus retroflexuse0
- Direction
- inhibitione0
- Value
- 100%e0
- Qualifier
- 150 g a.i. ha −1e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Compounds 4 , 43 and 44 showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at an application rate of 150 g a.i. ha −1”
Claim · model-written summary
Compounds 4, 43 and 44 may be candidates with a bleaching effect.
- Outcome
- novel candidates with a bleaching effecte0
Not reportedTaxon
Verbatim
e0“Compounds 4 , 43 and 44 may serve as novel candidates with a bleaching effect”