Abstract
Plant bacterial diseases can potentially damage agricultural products around the world, and few effective bactericides can manage these infections. Herein, to sequentially explore highly effective antibacterial alternatives, 1,2,3-triazole-tailored carbazoles were rationally fabricated. These compounds could suppress the growth of three main intractable pathogens including Xanthomonas oryzae pv oryzae (Xoo), X. axonopodis pv citri (Xac), and Pseudomonas syringae pv actinidiae (Psa) with lower EC50 values of 3.36 (3p), 2.87 (3p), and 4.57 μg/mL (3r), respectively. Pot experiments revealed that compound 3p could control the rice bacterial blight with protective and curative efficiencies of 53.23% and 50.78% at 200 μg/mL, respectively. Interestingly, the addition of 0.1% auxiliaries such as organic silicon and orange oil could significantly enhance the surface wettability of compound 3p toward rice leaves, resulting in improved control effectiveness of 65.50% and 61.38%, respectively. Meanwhile, compound 3r could clearly reduce the white pyogenic exudates triggered by Psa infection and afforded excellent control efficiencies of 79.42% (protective activity) and 78.74% (curative activity) at 200 μg/mL, which were quite better than those of commercial pesticide thiodiazole copper. Additionally, a plausible apoptosis mechanism for the antibacterial behavior of target compounds was proposed by flow cytometry, reactive oxygen species detection, and defensive enzyme (e.g., catalase and superoxide dismutase) activity assays. The current work can promote the development of 1,2,3-triazole-tailored carbazoles as prospective antibacterial alternatives bearing an intriguing mode of action.
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Claims 10
Claim · model-written summary
Compound 3p suppressed Xoo growth with EC50 3.36 μg/mL.
- Treatment
- 3pe1
- Interactor
- Xanthomonas oryzae pv oryzaeXanthomonas oryzaee0pathogen
- Outcome
- EC50 valuese1
- Value
- 3.36e1
Not reportedTaxon
Verbatim
e0“Xanthomonas oryzae pv oryzae (Xoo)”
e1“lower EC50 values of 3.36 (3p), 2.87 (3p), and 4.57 μg/mL (3r), respectively”
Claim · model-written summary
Compound 3p suppressed Xac growth with EC50 2.87 μg/mL.
- Treatment
- 3pe1
- Interactor
- X. axonopodis pv citri
Xanthomonas axonopodise0pathogen - Outcome
- EC50 valuese1
- Value
- 2.87e1
Not reportedTaxon
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“X. axonopodis pv citri (Xac)”
e1“lower EC50 values of 3.36 (3p), 2.87 (3p), and 4.57 μg/mL (3r), respectively”
Claim · model-written summary
Compound 3r suppressed Psa growth with EC50 4.57 μg/mL.
- Treatment
- 3re1
- Interactor
- Pseudomonas syringae pv actinidiae
Pseudomonas syringaee0pathogen - Outcome
- EC50 valuese1
- Value
- 4.57 μg/mLe1
Not reportedTaxon
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Pseudomonas syringae pv actinidiae (Psa)”
e1“lower EC50 values of 3.36 (3p), 2.87 (3p), and 4.57 μg/mL (3r), respectively”
Claim · model-written summary
Compound 3p had 53.23% protective control efficiency against rice bacterial blight.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“compound 3p could control the rice bacterial blight with protective and curative efficiencies of 53.23% and 50.78% at 200 μg/mL, respectively”
Claim · model-written summary
Compound 3p had 50.78% curative control efficiency against rice bacterial blight.
- Taxon
- rice
Oryza sativae0 - Treatment
- compound 3pe0
- Outcome
- curative efficienciese0
- Direction
- controle0
- Value
- 50.78%e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“compound 3p could control the rice bacterial blight with protective and curative efficiencies of 53.23% and 50.78% at 200 μg/mL, respectively”
Claim · model-written summary
Organic silicon improved wettability of 3p on rice leaves and control effectiveness to 65.50%.
- Taxon
- riceOryza sativae0
- Organ / stage
- leavese0
- Treatment
- organic silicone0
- Outcome
- surface wettability of compound 3p toward rice leavese0
- Direction
- enhancee0
- Value
- 65.50%e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the addition of 0.1% auxiliaries such as organic silicon and orange oil could significantly enhance the surface wettability of compound 3p toward rice leaves, resulting in improved control effectiveness of 65.50% and 61.38%, respectively”
Claim · model-written summary
Orange oil improved wettability of 3p on rice leaves and control effectiveness to 61.38%.
- Taxon
- riceOryza sativae0
- Organ / stage
- leavese0
- Treatment
- orange oile0
- Outcome
- surface wettability of compound 3p toward rice leavese0
- Direction
- enhancee0
- Value
- 61.38%e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the addition of 0.1% auxiliaries such as organic silicon and orange oil could significantly enhance the surface wettability of compound 3p toward rice leaves, resulting in improved control effectiveness of 65.50% and 61.38%, respectively”
Claim · model-written summary
Compound 3r reduced white pyogenic exudates induced by Psa.
- Treatment
- compound 3re0
- Interactor
- Psae0pathogen
- Outcome
- white pyogenic exudates triggered by Psa infectione0
- Direction
- reducee0
Not reportedTaxonComparator
Verbatim
e0“compound 3r could clearly reduce the white pyogenic exudates triggered by Psa infection”
Claim · model-written summary
Compound 3r had 79.42% protective control efficiency against Psa.
- Treatment
- 3re2
- Interactor
- Psae1pathogen
- Outcome
- protective activitye0
- Direction
- bettere0
- Value
- 79.42%e0
- Comparator
- commercial pesticide thiodiazole coppere0
Not reportedTaxon
Verbatim
e0“afforded excellent control efficiencies of 79.42% (protective activity) and 78.74% (curative activity) at 200 μg/mL, which were quite better than those of commercial pesticide thiodiazole copper”
e1“Psa infection”
e2“compound 3r could clearly reduce the white pyogenic exudates”
Claim · model-written summary
Compound 3r had 78.74% curative control efficiency against Psa.
- Treatment
- compound 3re0
- Interactor
- Psae0pathogen
- Outcome
- curative activitye0
- Direction
- bettere0
- Value
- 78.74%e0
- Comparator
- commercial pesticide thiodiazole coppere0
Not reportedTaxon
Verbatim
e0“compound 3r could clearly reduce the white pyogenic exudates triggered by Psa infection and afforded excellent control efficiencies of 79.42% (protective activity) and 78.74% (curative activity) at 200 μg/mL, which were quite better than those of commercial pesticide thiodiazole copper”
The same questions in other papers
silicon atom · organism · Oryza sativa (rice)Positive and negative results
17 papers in the same direction as this paper · 2 in the opposite direction
- negative
- no effect
- positive
16 papers more in this group
See all 20 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.