Abstract
Caragana is one of the most important genera of the plant family Fabaceae, and is famous for conventional folklore medicines applications. Therefore, the present investigation was designed to explore therapeutical potentials of various extracts of Caragana brachyantha Rech.f (Hexane, Ethyl acetate, n -Butanol, Methanol, aqueous) through in-vitro biological screening. The UHPLC-MS analysis of the extracts disclosed phytochemical composition and total bioactive contents. Ethyl acetate extract (CBEA) offered the highest phenolic (48.49±1.23 mgGAE/g extract) and flavonoid (16.48±0.26 mgRE/g extract) contents and also exhibited significant antioxidant activities. The observed antioxidant potential was further supported by Pearson correlation studies, which depicted a positive relationship between total phenolic contents (TPC) and total flavonoid contents (TFC). Methanolic extract (CBM) exhibited the highest anti-α-glucosidase activity (2.02±0.02 mmolACAE/g extract) while CBEA was found more active (96.02±3.24 mgKAE/g extract) in tyrosinase inhibition assay. This investigation suggests potential uses of Caragana brachyantha in nutraceutical and pharmaceutical products and thus offers a great industrial application.
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Claims 7
Claim · model-written summary
Ethyl acetate extract had the highest phenolic content (48.49±1.23 mgGAE/g extract) of the extracts tested.
Verbatim
t0“Caragana brachyantha Rech.f”
e1“Ethyl acetate extract (CBEA) offered the highest phenolic (48.49±1.23 mgGAE/g extract) and flavonoid (16.48±0.26 mgRE/g extract) contents and also exhibited significant antioxidant activities”
Claim · model-written summary
Ethyl acetate extract had the highest flavonoid content (16.48±0.26 mgRE/g extract) of the extracts tested.
Verbatim
t0“Caragana brachyantha Rech.f”
e1“Ethyl acetate extract (CBEA) offered the highest phenolic (48.49±1.23 mgGAE/g extract) and flavonoid (16.48±0.26 mgRE/g extract) contents and also exhibited significant antioxidant activities”
Claim · model-written summary
Methanolic extract had the highest anti-α-glucosidase activity (2.02±0.02 mmolACAE/g extract).
Verbatim
t0“Caragana brachyantha Rech.f”
e2“Methanolic extract (CBM) exhibited the highest anti-α-glucosidase activity (2.02±0.02 mmolACAE/g extract)”
Claim · model-written summary
CBEA was more active in tyrosinase inhibition (96.02±3.24 mgKAE/g extract) than the other extracts.
Verbatim
t0“Caragana brachyantha Rech.f”
e3“while CBEA was found more active (96.02±3.24 mgKAE/g extract) in tyrosinase inhibition assay”
Claim · model-written summary
Total phenolic contents and total flavonoid contents were positively related across the extracts (Pearson correlation).
Verbatim
t0“Caragana brachyantha Rech.f”
e4“Pearson correlation studies, which depicted a positive relationship between total phenolic contents (TPC) and total flavonoid contents (TFC)”
Claim · model-written summary
Ethyl acetate extract exhibited significant antioxidant activities.
Verbatim
t0“Caragana brachyantha Rech.f”
e1“Ethyl acetate extract (CBEA) offered the highest phenolic (48.49±1.23 mgGAE/g extract) and flavonoid (16.48±0.26 mgRE/g extract) contents and also exhibited significant antioxidant activities”
Claim · model-written summary
The authors suggest potential uses of Caragana brachyantha in nutraceutical and pharmaceutical products.
Verbatim
e5“This investigation suggests potential uses of Caragana brachyantha in nutraceutical and pharmaceutical products”