Abstract
Abstract One icetexane diterpenoid, demethylsalvicanol ( 1 ) and four abietane diterpenoids, sageone ( 2 ), 20‐deoxocarnosol ( 3 ), 11,12,20‐trihydroxy‐abieta‐8,11,13‐triene ( 4 ), and 7α α ‐ethoxyrosmanol ( 5 ) were isolated from the n ‐hexane layer of the leaves and twigs of Rosmarinus officinalis L. Chemical structures of compounds were identified by ESI‐MS, 1D‐, 2D‐NMR spectra and by comparison of the spectral data in the literature. Compounds 1 ‐ 5 were evaluated anti‐inflammatory activity by inhibitory NO production, LPS stimulated on RAW 264.7 cells. At a concentration of 100 μM, compound 4 exhibited inhibitory percentage of 34.7±1.8 %, meanwhile compounds 1‐3 and 5 showed cytotoxic effect. After dilution to concentration of 20 μM, except compound 1 and 2 , compounds 3‐5 did not show cytotoxic effect. Their NO inhibitory productions were ranging from 20.5±2.4 % to 26.7±1.9 %. Compounds 1 , 3 and 4 have been reported for the first time from the Rosmarinus genus.
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Claims 2
Claim · model-written summary
Five named diterpenoids were isolated from rosemary leaves and twigs.
- Taxon
- Rosmarinus officinalis L.
Salvia rosmarinuse0 - Organ / stage
- leaves and twigse0
- Outcome
- demethylsalvicanol ( 1 ) and four abietane diterpenoids, sageone ( 2 ), 20‐deoxocarnosol ( 3 ), 11,12,20‐trihydroxy‐abieta‐8,11,13‐triene ( 4 ), and 7α α ‐ethoxyrosmanol ( 5 )e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“One icetexane diterpenoid, demethylsalvicanol ( 1 ) and four abietane diterpenoids, sageone ( 2 ), 20‐deoxocarnosol ( 3 ), 11,12,20‐trihydroxy‐abieta‐8,11,13‐triene ( 4 ), and 7α α ‐ethoxyrosmanol ( 5 ) were isolated from the n ‐hexane layer of the leaves and twigs of Rosmarinus officinalis L.”
Claim · model-written summary
Compounds 1, 3 and 4 were reported for the first time from Rosmarinus.
- Taxon
- RosmarinusSalvia subgen. Rosmarinuse0
- Outcome
- Compounds 1 , 3 and 4 have been reported for the first timee0
Verbatim
e0“Compounds 1 , 3 and 4 have been reported for the first time from the Rosmarinus genus.”