Abstract
Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard. Spectroscopic and spectrometric methods and the comparison of their results with those given in the literature were used to ascertain their structures. Furthermore, the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a). Extracts, fractions, and isolated compounds were assessed for their antioxidant, urease, and α-glucosidase inhibitory activities. Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM, while rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively. The present study enriches the chemistry of Guiboutia ehie and provides further evidence on its bioactive constituents, which might help in the development of hypoglycaemic drugs.
Abstract from the paper’s OpenAlex record; open copy licensed cc-by-nc-nd. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 6
Claim · model-written summary
Thirteen compounds were identified from leaves and stem bark.
- Taxon
- Guibourtia ehieGuibourtia ehiee0
- Organ / stage
- leaves and stem barke0
- Outcome
- compoundse0
- Value
- Thirteen compoundse0
Verbatim
e0“Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard.”
Claim · model-written summary
Acetylation yielded a new derivative.
- Taxon
- Guibourtia ehieGuibourtia ehiet0
- Outcome
- a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a)e0
Not reportedDirection
Verbatim
e0“the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a).”
t0“Guibourtia ehie”
Claim · model-written summary
Compound 1 had potent DPPH antioxidant activity with IC50 36.4 ± 0.2 µM.
- Taxon
- Guibourtia ehieGuibourtia ehiet0
- Outcome
- antioxidant activity in the DPPHe0
- Direction
- potente0
- Value
- 36.4 ± 0.2 µMe0
Verbatim
e0“Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM”
t0“Guibourtia ehie”
Claim · model-written summary
Rhaponticin had strong α-glucosidase inhibition with IC50 35.5 ± 0.1 µM.
- Taxon
- Guibourtia ehieGuibourtia ehiet0
- Outcome
- α-glucosidase inhibitory activitye0
- Direction
- stronge0
- Value
- 35.5 ± 0.1e0
Verbatim
e0“rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively.”
t0“Guibourtia ehie”
Claim · model-written summary
2,6-dimethoxybenzoquinone had strong α-glucosidase inhibition with IC50 25.5 ± 0.2 µM.
- Taxon
- Guibourtia ehieGuibourtia ehiet0
- Outcome
- α-glucosidase inhibitory activitye0
- Direction
- stronge0
- Value
- 25.5 ± 0.2e0
Verbatim
e0“rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively.”
t0“Guibourtia ehie”
Claim · model-written summary
Taraxerol had strong α-glucosidase inhibition with IC50 43.4 ± 0.3 µM.
- Taxon
- Guibourtia ehieGuibourtia ehiet0
- Outcome
- α-glucosidase inhibitory activitye0
- Direction
- stronge0
- Value
- 43.4 ± 0.3 µMe0
Verbatim
e0“rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively.”
t0“Guibourtia ehie”