Abstract
Memecylon umbellatum, M. edule, M. talbotianum, M. malabaricum, and M. wightii species belong to the family Melastomataceae. The genus is well-known traditional medicinal herb used to treat skin diseases. The goal is to compare the metabolite makeup of the five Memecylon spp. and to evaluate the extract's anti-inflammatory and antiprotease activities. UPLC-ESI-QTOF-MS was used to profile untargeted metabolites in a water/methanol extract, followed by statistical analysis with PCA and HCA. Anti-inflammatory and antiprotease activity were determined by inhibiting soybean 15-lipoxygenase and Protease. Phenols and flavonoids are the most abundant secondary metabolites in Memecylon spp. Principal component analysis (PCA) was used to identify marker chemicals from five species, tocopherol, isorhamnetin 3-glucoside, isothalic acid, stearoylglycerol, and pyrrolidine. The Memecylon spp. maybe clustered into two groups based on principal component analysis, with M. malabaricum & M. wightii clustered together and M. umbellatum, M. edule & M. talbotianum forming another clustered. The anti-inflammatory (Soybean 15-lipoxygenase inhibition) and antiprotease activities (Trypsin and thrombin Inhibition) of crude extracts suggested that M. malabaricum and M. talbotianum extracts exhibited higher inhibition compared to the other three species. These data suggest that differences in metabolite profiles might be connected to differences in the bioactivity of the five plant extracts examined. The untargeted UPLC-ESI-QTOF-MS technique is efficient for identifying bioactive components of Memecylon spp.
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Claims 8
Claim · model-written summary
Phenols and flavonoids were the most abundant secondary metabolites.
.jpg?width=60){kind=small}
MemecylonOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“Phenols and flavonoids are the most abundant secondary metabolites in Memecylon spp.”
Claim · model-written summary
PCA identified five marker chemicals for the species.
- Outcome
- marker chemicalse0
- Value
- five speciese0
- Qualifier
- tocopherol, isorhamnetin 3-glucoside, isothalic acid, stearoylglycerol, and pyrrolidinee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“identify marker chemicals from five species, tocopherol, isorhamnetin 3-glucoside, isothalic acid, stearoylglycerol, and pyrrolidine”
t0“Memecylon species”
Claim · model-written summary
PCA grouped M. malabaricum with M. wightii.
- Taxon
- M. malabaricum & M. wightii
Memecylon malabaricume0 - Outcome
- clustered togethere0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“M. malabaricum & M. wightii clustered together”
Claim · model-written summary
PCA grouped M. umbellatum, M. edule and M. talbotianum.
- Taxon
- M. umbellatum, M. edule & M. talbotianum
Memecylon edule
Memecylon umbellatum.jpg?width=60)
Memecylon talbotianume0 - Outcome
- forming another clusterede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“M. umbellatum, M. edule & M. talbotianum forming another clustered”
Claim · model-written summary
M. malabaricum extract had higher enzyme inhibition than the other three species.
- Taxon
- M. malabaricumMemecylon malabaricume0
- Outcome
- inhibitione0
- Direction
- highere0
- Comparator
- other three speciese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“M. malabaricum and M. talbotianum extracts exhibited higher inhibition compared to the other three species”
Claim · model-written summary
M. talbotianum extract had higher enzyme inhibition than the other three species.
- Taxon
- M. talbotianumMemecylon talbotianume0
- Outcome
- inhibitione0
- Direction
- highere0
- Comparator
- other three speciese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“M. malabaricum and M. talbotianum extracts exhibited higher inhibition compared to the other three species”
Claim · model-written summary
The authors suggest metabolite profiles may relate to extract bioactivity.
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“differences in metabolite profiles might be connected to differences in the bioactivity of the five plant extracts examined”
t0“Memecylon species”
Claim · model-written summary
Untargeted UPLC-ESI-QTOF-MS was described as efficient for identifying bioactive components.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The untargeted UPLC-ESI-QTOF-MS technique is efficient for identifying bioactive components of Memecylon spp.”