Abstract
The combination experiments of X-irradiation with some mixture solutions of various nucleotides were undertaken with the chromosomes of the ovular tissue cells of Trillium kamtschaticum.Thymidine triphosphate did neither reduce nor increase significantly both frequencies of simple and rejoined breaks produced by X-rays. An equimolar mixture solution of three deoxyribonucleotides of dATP, dGTP and dCTP did not also result in any significant difference in the frequency of breaks from the X-ray control.When the four components commonly found in DNA or RNA were supplied as the form of nucleoside or nucleotide, there was a tendency toward the decrease of the frequency of breaks. The significant decrease in the frequency of simple breaks from that of the X-ray control was recognized in the three cases of (dATP+dGTP+dCTP+dTTP)+, (dATP+dGTP+dCTP+UTP)+, and (ATP+GTP+CTP+dTTP)+X-ray treatments.These results suggest the involvement of DNA synthesis in the process of reunion of X-ray-induced breaks, at least in restitution to restore the original continuity of chromosomes.
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Claims 8
Claim · model-written summary
Thymidine triphosphate did not significantly change simple break frequency.
- Treatment
- Thymidine triphosphatee0
- Outcome
- frequencies of simplee0
- Direction
- neither reduce nor increasee0
Not reportedTaxonComparator
Verbatim
e0“Thymidine triphosphate did neither reduce nor increase significantly both frequencies of simple and rejoined breaks produced by X-rays”
Claim · model-written summary
Thymidine triphosphate did not significantly change rejoined break frequency.
Not reportedTaxonComparator
Verbatim
e0“Thymidine triphosphate did neither reduce nor increase significantly both frequencies of simple and rejoined breaks produced by X-rays”
Claim · model-written summary
The dATP, dGTP and dCTP mixture did not significantly change break frequency relative to X-ray control.
- Treatment
- equimolar mixture solution of three deoxyribonucleotides of dATP, dGTP and dCTPe0
- Outcome
- frequency of breakse0
- Direction
- did not also result in any significant differencee0
- Comparator
- X-ray controle0
Not reportedTaxon
Verbatim
e0“An equimolar mixture solution of three deoxyribonucleotides of dATP, dGTP and dCTP did not also result in any significant difference in the frequency of breaks from the X-ray control”
Claim · model-written summary
Supplying four DNA or RNA components tended to decrease break frequency.
- Treatment
- four components commonly found in DNA or RNAe0
- Outcome
- frequency of breakse0
- Direction
- decreasee0
Not reportedTaxonComparator
Verbatim
e0“When the four components commonly found in DNA or RNA were supplied as the form of nucleoside or nucleotide, there was a tendency toward the decrease of the frequency of breaks”
Claim · model-written summary
The dATP+dGTP+dCTP+dTTP treatment significantly decreased simple breaks.
- Treatment
- (dATP+dGTP+dCTP+dTTP)+e0
- Outcome
- frequency of simple breakse0
- Direction
- decreasee0
- Comparator
- X-ray controle0
Not reportedTaxon
Verbatim
e0“The significant decrease in the frequency of simple breaks from that of the X-ray control was recognized in the three cases of (dATP+dGTP+dCTP+dTTP)+”
Claim · model-written summary
The dATP+dGTP+dCTP+UTP treatment significantly decreased simple breaks.
Not reportedTaxonComparator
Verbatim
e0“The significant decrease in the frequency of simple breaks from that of the X-ray control was recognized in the three cases of (dATP+dGTP+dCTP+dTTP)+, (dATP+dGTP+dCTP+UTP)+”
Claim · model-written summary
The ATP+GTP+CTP+dTTP treatment significantly decreased simple breaks.
Not reportedTaxonComparator
Verbatim
e0“The significant decrease in the frequency of simple breaks from that of the X-ray control was recognized in the three cases of (dATP+dGTP+dCTP+dTTP)+, (dATP+dGTP+dCTP+UTP)+, and (ATP+GTP+CTP+dTTP)+X-ray treatments”
Claim · model-written summary
The findings suggest DNA synthesis participates in reunion of X-ray-induced breaks.
Not reportedTaxon
Verbatim
e0“These results suggest the involvement of DNA synthesis in the process of reunion of X-ray-induced breaks”