Abstract
The effects of the oncostatic extracts from Rheum officinale rhizomes on the activity of meristematic cells from Allium cepa roots were investigated. A statistically significant decrease of the IM value was noted as well as of the total number of mitoses during incubation. The disturbances in the course of mitosis and cytokinesis are described and discussed. The kind of disturbances during postincubation points to damage of the S and G2 phases of the interphase nuclei. Cytochemical and autoradiographic studies demonstrated a diminished intensity of staining of DNA and RNA and inhibition of DNA synthesis during incubation, this leading in tum to a lower intensity of protein staining in postincubation. Disturbances in mitosis and cytokinesis after treatment wth 2,6-dihydroxyantraquinone, supposed to be the antimitotically active compound of the extract, are the same as those produced by the total water soluble fraction.
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Claims 8
Claim · model-written summary
Extract exposure significantly decreased the mitotic index of onion root meristem cells.
- Taxon
- Allium cepa
Allium cepat0 - Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- IM valuee0
- Direction
- decreasee0
Not reportedOrgan / stageComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“A statistically significant decrease of the IM value was noted as well as of the total number of mitoses during incubation.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Extract exposure significantly decreased the total number of mitoses during incubation.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- total number of mitosese0
- Direction
- decreasee0
Not reportedOrgan / stageComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“A statistically significant decrease of the IM value was noted as well as of the total number of mitoses during incubation.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Extract exposure disturbed mitosis and cytokinesis.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- disturbances in the course of mitosis and cytokinesise0
Not reportedOrgan / stageComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The disturbances in the course of mitosis and cytokinesis are described and discussed.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Postincubation disturbances suggest damage to S and G2 phases.
- Taxon
- Allium cepaAllium cepat0
- Outcome
- damage of the S and G2 phasese0
- Qualifier
- disturbances during postincubatione0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The kind of disturbances during postincubation points to damage of the S and G2 phases of the interphase nuclei.”
t0“Allium cepa”
Claim · model-written summary
Extract exposure reduced intensity of staining of DNA and RNA.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- intensity of staining of DNA and RNAe0
- Direction
- diminishede0
Not reportedOrgan / stageComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cytochemical and autoradiographic studies demonstrated a diminished intensity of staining of DNA and RNA and inhibition of DNA synthesis during incubation, this leading in tum to a lower intensity of protein staining in postincubation.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Extract exposure reduced DNA synthesis.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- DNA synthesise0
- Direction
- inhibitione0
Not reportedOrgan / stageComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cytochemical and autoradiographic studies demonstrated a diminished intensity of staining of DNA and RNA and inhibition of DNA synthesis during incubation, this leading in tum to a lower intensity of protein staining in postincubation.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Extract exposure reduced intensity of protein staining.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- oncostatic extracts from Rheum officinale rhizomest1
- Outcome
- intensity of protein staininge0
- Direction
- lowere0
Not reportedOrgan / stageComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cytochemical and autoradiographic studies demonstrated a diminished intensity of staining of DNA and RNA and inhibition of DNA synthesis during incubation, this leading in tum to a lower intensity of protein staining in postincubation.”
t0“Allium cepa”
t1“oncostatic extracts from Rheum officinale rhizomes”
Claim · model-written summary
Treatment with 2,6-dihydroxyantraquinone produced the same mitotic and cytokinetic disturbances as the total water soluble fraction.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- treatment wth 2,6-dihydroxyantraquinonee0
- Outcome
- Disturbances in mitosis and cytokinesise0
- Direction
- samee0
- Comparator
- total water soluble fractione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Disturbances in mitosis and cytokinesis after treatment wth 2,6-dihydroxyantraquinone, supposed to be the antimitotically active compound of the extract, are the same as those produced by the total water soluble fraction.”
t0“Allium cepa”
The same questions in other papers
botanical · quality: protein · Allium cepa (onion)Positive and negative results
2 papers in the same direction as this paper · 3 in the opposite direction
- positive
- positive
- positive
2 papers more in this group
See all 6 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.