Abstract
Abnormal temperature caused by global climate change threatens the rice production. Defense signaling network for chilling has been uncovered in plants. However, less is known about repairing DNA damage produced from overwhelmed defense and its evolution during domestication. Here, we genetically identified a major QTL, COLD11 , using the data-merging genome-wide association study based on an algorithm combining polarized data from two subspecies, indica and japonica , into one system. Rice loss-of-function mutations of COLD11 caused reduced chilling tolerance. Genome evolution analysis of representative rice germplasms suggested that numbers of GCG sequence repeats in the first exon of COLD11 were subjected to strong domestication selection during the northern expansion of rice planting. The repeat numbers affected the biochemical activity of DNA repair protein COLD11/RAD51A1 in renovating DNA damage under chilling stress. Our findings highlight a potential way to finely manipulate key genes in rice genome and effectively improve chilling tolerance through molecular designing.
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Claims 5
Claim · model-written summary
A major QTL, COLD11, was identified in rice by a data-merging genome-wide association study combining indica and japonica data.
- Taxon
- rice
Oryza sativat0 - Material
- indica and japonicae1
- Gene
- COLD11e0
- Outcome
- major QTLe0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Natural variation of codon repeats in COLD11 endows rice with chilling resilience”
e0“we genetically identified a major QTL, COLD11, using the data-merging genome-wide association study”
e1“combining polarized data from two subspecies, indica and japonica, into one system”
Claim · model-written summary
Loss-of-function mutations of COLD11 in rice caused reduced chilling tolerance.
- Taxon
- riceOryza sativat0
- Treatment
- loss-of-function mutationse2
- Gene
- COLD11e2
- Outcome
- chilling tolerancee2
- Direction
- reducede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Natural variation of codon repeats in COLD11 endows rice with chilling resilience”
e2“Rice loss-of-function mutations of COLD11 caused reduced chilling tolerance”
Claim · model-written summary
Numbers of GCG sequence repeats in the first exon of COLD11 were subjected to strong domestication selection during the northern expansion of rice planting.
- Taxon
- riceOryza sativat0
- Material
- representative rice germplasmse3
- Organ / stage
- first exone3
- Gene
- COLD11e3
- Outcome
- numbers of GCG sequence repeatse3
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Natural variation of codon repeats in COLD11 endows rice with chilling resilience”
e3“Genome evolution analysis of representative rice germplasms suggested that numbers of GCG sequence repeats in the first exon of COLD11 were subjected to strong domestication selection during the northern expansion of rice planting”
Claim · model-written summary
The number of repeats in COLD11 affected the biochemical activity of the DNA repair protein COLD11/RAD51A1 under chilling stress.
- Taxon
- riceOryza sativat0
- Treatment
- repeat numberse4
- Gene
- COLD11/RAD51A1e4
- Outcome
- biochemical activity of DNA repair proteine4
- Qualifier
- under chilling stresse4
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Natural variation of codon repeats in COLD11 endows rice with chilling resilience”
e4“The repeat numbers affected the biochemical activity of DNA repair protein COLD11/RAD51A1 in renovating DNA damage under chilling stress”
Claim · model-written summary
Manipulating key genes in the rice genome may effectively improve chilling tolerance through molecular design.
- Taxon
- riceOryza sativat0
- Outcome
- improve chilling tolerancee5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Natural variation of codon repeats in COLD11 endows rice with chilling resilience”
e5“a potential way to finely manipulate key genes in rice genome and effectively improve chilling tolerance through molecular designing”
The same questions in other papers
loss of function · tolerance: abiotic · Oryza sativa (rice)Positive and negative results
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- positive
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