Abstract
Medicinal plants are considered a major source for discovering novel effective drugs. To our knowledge, no studies have reported the chemical composition and biological activities of Moroccan Lactuca saligna extracts. In this context, this study aims to characterize the polyphenolic compounds distributed in hydro-methanolic extracts of L. saligna and evaluate their antioxidant and antibacterial activities; in addition, in silico analysis based on molecular docking and ADMET was performed to predict the antibacterial activity of the identified phenolic compounds. Our results showed the identification of 29 among 30 detected phenolic compounds with an abundance of dicaffeoyltartaric acid, luteolin 7-glucoronide, 3,5-di-O-caffeoylquinic acid, and 5-caffeoylquinic acid with 472.77, 224.30, 196.79, and 171.74 mg/kg of dried extract, respectively. Additionally, antioxidant activity assessed by DPPH scavenging activity, ferric reducing antioxidant power (FRAP) assay, and ferrous ion-chelating (FIC) assay showed interesting antioxidant activity. Moreover, the results showed remarkable antibacterial activity against Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Listeria monocytogenes with minimum inhibitory concentrations between 1.30 ± 0.31 and 10.41 ± 0.23 mg/mL. Furthermore, in silico analysis identified three compounds, including Apigenin 7-O-glucuronide, Quercetin-3-O-glucuronide, and 3-p-Coumaroylquinic acid as potent candidates for developing new antibacterial agents with acceptable pharmacokinetic properties. Hence, L. saligna can be considered a source of phytochemical compounds with remarkable activities, while further in vitro and in vivo studies are required to explore the main biological activities of this plant.
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Claims 8
Claim · model-written summary
The extract contained 29 identified phenolic compounds out of 30 detected.
- Taxon
- Lactuca saligna
Lactuca salignae0 - Outcome
- phenolic compoundse1
- Value
- 29 among 30e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Moroccan Lactuca saligna extracts”
e1“identification of 29 among 30 detected phenolic compounds”
Claim · model-written summary
Dicaffeoyltartaric acid was abundant at 472.77 mg/kg dried extract.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- dicaffeoyltartaric acide1
- Value
- 472.77e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Moroccan Lactuca saligna extracts”
e1“dicaffeoyltartaric acid, luteolin 7-glucoronide, 3,5-di-O-caffeoylquinic acid, and 5-caffeoylquinic acid with 472.77, 224.30, 196.79, and 171.74 mg/kg of dried extract, respectively”
Claim · model-written summary
Luteolin 7-glucoronide was abundant at 224.30 mg/kg dried extract.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- luteolin 7-glucoronidee1
- Value
- 224.30e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“luteolin 7-glucoronide, 3,5-di-O-caffeoylquinic acid, and 5-caffeoylquinic acid with 472.77, 224.30, 196.79, and 171.74 mg/kg of dried extract, respectively”
Claim · model-written summary
3,5-di-O-caffeoylquinic acid was abundant at 196.79 mg/kg dried extract.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- 3,5-di-O-caffeoylquinic acide1
- Value
- 196.79e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“3,5-di-O-caffeoylquinic acid, and 5-caffeoylquinic acid with 472.77, 224.30, 196.79, and 171.74 mg/kg of dried extract, respectively”
Claim · model-written summary
5-caffeoylquinic acid was abundant at 171.74 mg/kg dried extract.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- 5-caffeoylquinic acide1
- Value
- 171.74 mg/kge1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“5-caffeoylquinic acid with 472.77, 224.30, 196.79, and 171.74 mg/kg of dried extract, respectively”
Claim · model-written summary
The extracts showed antioxidant activity in three assays.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- antioxidant activitye1
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“antioxidant activity assessed by DPPH scavenging activity, ferric reducing antioxidant power (FRAP) assay, and ferrous ion-chelating (FIC) assay showed interesting antioxidant activity”
Claim · model-written summary
The extracts inhibited six named bacteria with minimum inhibitory concentrations between 1.30 ± 0.31 and 10.41 ± 0.23 mg/mL.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- antibacterial activitye1
- Value
- between 1.30 ± 0.31 and 10.41 ± 0.23 mg/mLe1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“remarkable antibacterial activity against Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Listeria monocytogenes with minimum inhibitory concentrations between 1.30 ± 0.31 and 10.41 ± 0.23 mg/mL”
Claim · model-written summary
Docking and ADMET analysis identified three phenolics as candidate antibacterial agents with acceptable pharmacokinetics.
- Taxon
- Lactuca salignaLactuca salignae0
- Outcome
- potent candidates for developing new antibacterial agentse1
- Value
- three compoundse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Lactuca saligna”
e1“in silico analysis identified three compounds, including Apigenin 7-O-glucuronide, Quercetin-3-O-glucuronide, and 3-p-Coumaroylquinic acid as potent candidates for developing new antibacterial agents with acceptable pharmacokinetic properties”