Abstract
Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L. (Tripolium pannonicum), and their chemical structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry. Comprehensive structural analysis revealed the presence of distinct aglycone and glycosidic moieties, along with complex acylation patterns. The acyl chains of pannosides, 3-hydroxybutyrate (3-HB) residues, were derivatized with (S)- and (R)- phenylglycine methyl ester to resolve the absolute configurations of the chiral centers in 3-HB. Then, the acyl chain-containing saponins, pannosides were evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B). Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3. These findings suggest that saponins from A. tripolium exhibit potential antiviral activities and could be further explored for their therapeutic applications.
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Claims 6
Claim · model-written summary
Four previously undescribed pentacyclic triterpenoid saponins, pannosides F-I, were isolated from Aster tripolium.
- Taxon
- Aster tripolium L.
Tripolium pannonicum subsp. tripoliume0 - Outcome
- previously undescribed pentacyclic triterpenoid saponinse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
Claim · model-written summary
Structural analysis of the pannosides revealed distinct aglycone and glycosidic moieties with complex acylation patterns.
- Taxon
- Aster tripolium L.Tripolium pannonicum subsp. tripoliume0
- Outcome
- distinct aglycone and glycosidic moieties, along with complex acylation patternse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
e1“Comprehensive structural analysis revealed the presence of distinct aglycone and glycosidic moieties, along with complex acylation patterns”
Claim · model-written summary
Derivatization with (S)- and (R)-phenylglycine methyl ester resolved the absolute configurations of the chiral centers in the 3-HB acyl residues of the pannosides.
- Taxon
- Aster tripolium L.Tripolium pannonicum subsp. tripoliume0
- Outcome
- absolute configurations of the chiral centers in 3-HBe1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
e1“to resolve the absolute configurations of the chiral centers in 3-HB”
Claim · model-written summary
Pannosides exhibited antiviral activity against enterovirus A71 (EV71).
- Taxon
- Aster tripolium L.Tripolium pannonicum subsp. tripoliume0
- Interactor
- enterovirus A71 (EV71)
Enterovirus A71e1pathogen - Compound
- Pannosidese2
- Outcome
- antiviral activitiese2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
e1“evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B)”
e2“Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3”
Claim · model-written summary
Pannosides exhibited antiviral activity against coxsackievirus B3 (CVB3).
- Taxon
- Aster tripolium L.Tripolium pannonicum subsp. tripoliume0
- Interactor
- coxsackievirus B3 (CVB3)Coxsackievirus B3e1pathogen
- Compound
- Pannosidese2
- Outcome
- antiviral activitiese2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
e1“evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B)”
e2“Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3”
Claim · model-written summary
Pannosides exhibited antiviral activity against rhinovirus 1B (HRV1B).
- Taxon
- Aster tripolium L.Tripolium pannonicum subsp. tripoliume0
- Interactor
- rhinovirus 1B (HRV1B)e1pathogen
- Compound
- Pannosidese2
- Outcome
- antiviral activitiese2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L.”
e1“evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B)”
e2“Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3”