Abstract
Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome, traditionally used in Ayahuasca preparations. Despite its cultural importance, research on its chemical composition and biological activities, which may have therapeutic potential, is limited. This study investigated the volatile and non-volatile secondary metabolites of D. pubipetala leaves, their antioxidant capacity, and their antibacterial and antifungal activities. Volatile compounds were identified using gas chromatography-mass spectrometry (GC-MS) coupled to solid-phase microextraction (SPME), while non-volatile compounds were annotated using UHPLC-MS/MS-ESI-Q-TOF. Antioxidant capacity was evaluated by DPPH assay, and antimicrobial activity was assessed in vitro against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida species (C. albicans, C. tropicalis, C. glabrata). GC-MS analysis revealed 25 predominant volatile compounds, including ethyl dodecanoate, ethyl tetradecanoate, nonanoic acid, and 5-methylhexan-2-one, with documented antifungal, antioxidant, and antimicrobial activities. The crude extract and ethyl acetate fraction showed strong antioxidant capacity (EC50 9.83 µg/mL and 6.42 µg/mL, respectively), and antifungal effects were observed against Candida species. This study provides the first comprehensive investigation of the antioxidant capacity and antibacterial and antifungal activities of D. pubipetala, together with a detailed chemical profile of its volatile compounds.
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Claims 4
Claim · model-written summary
GC-MS identified 25 predominant volatile compounds in Diplopterys pubipetala leaves, including ethyl dodecanoate, ethyl tetradecanoate, nonanoic acid and 5-methylhexan-2-one.
- Taxon
- Diplopterys pubipetala
_W._R._Anderson_%5E_C._Davis_-_Flickr_-_Alex_Popovkin%2C_Bahia%2C_Brazil_(2).jpg?width=60)
Diplopterys pubipetalae0 - Outcome
- predominant volatile compoundse1
- Value
- 25e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_W._R._Anderson_%5E_C._Davis_-_Flickr_-_Alex_Popovkin%2C_Bahia%2C_Brazil_(2).jpg?width=500)
Verbatim
e0“Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome”
e1“GC-MS analysis revealed 25 predominant volatile compounds, including ethyl dodecanoate, ethyl tetradecanoate, nonanoic acid, and 5-methylhexan-2-one”
Claim · model-written summary
The crude extract of Diplopterys pubipetala leaves showed strong antioxidant capacity, with EC50 9.83 µg/mL.
- Taxon
- Diplopterys pubipetalaDiplopterys pubipetalae0
- Material
- crude extracte2
- Outcome
- antioxidant capacitye2
- Value
- 9.83 µg/mLe2
- Qualifier
- stronge2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome”
e2“The crude extract and ethyl acetate fraction showed strong antioxidant capacity (EC50 9.83 µg/mL and 6.42 µg/mL, respectively)”
Claim · model-written summary
The ethyl acetate fraction of Diplopterys pubipetala leaves showed strong antioxidant capacity, with EC50 6.42 µg/mL.
- Taxon
- Diplopterys pubipetalaDiplopterys pubipetalae0
- Material
- ethyl acetate fractione2
- Outcome
- antioxidant capacitye2
- Value
- 6.42 µg/mLe2
- Qualifier
- stronge2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome”
e2“The crude extract and ethyl acetate fraction showed strong antioxidant capacity (EC50 9.83 µg/mL and 6.42 µg/mL, respectively)”
Claim · model-written summary
Antifungal effects of Diplopterys pubipetala were observed against Candida species.
- Taxon
- Diplopterys pubipetalaDiplopterys pubipetalae0
- Outcome
- antifungal effectse3
CandidaOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome”
e3“antifungal effects were observed against Candida species”