Abstract
Medicinal plants have long served as a fundamental source of therapeutic agents, providing a bridge between traditional healthcare practices and modern drug discovery. The present study investigates the phytochemical composition and in-vitro anticoagulant and thrombolytic activities of Proboscidea louisianica leaves. Fresh leaves were collected from rural areas of Korangi, Kakinada district, India, during the rainy season and subjected to shade drying followed by Soxhlet extraction using n-hexane. Preliminary phytochemical screening revealed the presence of bioactive constituents such as steroids, proteins, amino acids, tannins, flavonoids, phenols, saponins, and glycosides, while carbohydrates were absent. The anticoagulant activity was evaluated using the plasma recalcification (prothrombin time) method, where the extract showed a concentration-dependent prolongation of clotting time compared to the saline control. Thrombolytic activity was assessed by an in-vitro clot lysis assay using human blood clots, which demonstrated moderate clot lysis potential that increased with higher concentrations of the extract when compared with streptokinase as the positive control. The findings suggest that Proboscidea louisianica leaf extract possesses promising anticoagulant and thrombolytic properties, which may be attributed to its rich phytochemical content. These results support the traditional use of medicinal plants and indicate the potential of Proboscidea louisianica as a natural source for developing novel antithrombotic agents.
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Claims 4
Claim · model-written summary
Screening detected steroids, proteins, and amino acids in Proboscidea louisianica leaves.
- Taxon
- Proboscidea louisianica
Proboscidea louisianicat0 - Organ / stage
- LEAVESt0
- Outcome
- steroids, proteins, amino acidse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Preliminary phytochemical screening revealed the presence of bioactive constituents such as steroids, proteins, amino acids, tannins, flavonoids, phenols, saponins, and glycosides, while carbohydrates were absent.”
t0“PROBOSCIDEA LOUISIANICA LEAVES”
Claim · model-written summary
Screening detected tannins, flavonoids, and phenols in Proboscidea louisianica leaves.
- Taxon
- Proboscidea louisianicaProboscidea louisianicat0
- Organ / stage
- LEAVESt0
- Outcome
- tannins, flavonoids, phenolse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Preliminary phytochemical screening revealed the presence of bioactive constituents such as steroids, proteins, amino acids, tannins, flavonoids, phenols, saponins, and glycosides, while carbohydrates were absent.”
t0“PROBOSCIDEA LOUISIANICA LEAVES”
Claim · model-written summary
Screening detected saponins and glycosides in Proboscidea louisianica leaves.
- Taxon
- Proboscidea louisianicaProboscidea louisianicat0
- Organ / stage
- LEAVESt0
- Outcome
- saponins, and glycosidese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Preliminary phytochemical screening revealed the presence of bioactive constituents such as steroids, proteins, amino acids, tannins, flavonoids, phenols, saponins, and glycosides, while carbohydrates were absent.”
t0“PROBOSCIDEA LOUISIANICA LEAVES”
Claim · model-written summary
Screening did not detect carbohydrates in Proboscidea louisianica leaves.
- Taxon
- Proboscidea louisianicaProboscidea louisianicat0
- Organ / stage
- LEAVESt0
- Outcome
- carbohydrates were absente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“while carbohydrates were absent.”
t0“PROBOSCIDEA LOUISIANICA LEAVES”