Abstract
Memecylon amoenum is traditionally employed across West Africa for treating waist pains, diarrhoea, wounds, toothache and various skin ailments. The study aimed to identify major phytoconstituents using standard phytochemical screening, chromatographic separation, and FTIR analysis and to evaluate the biological activities of the methanol and petroleum ether leaves extracts. Phytochemical investigations revealed twelve constituents in the pulverized plant material and eleven in the methanolic extract, while the petroleum ether extract contained six. In the DPPH assay, the methanol and petroleum ether extracts of M. amoenum demonstrated IC₅₀ values of 11.42 ± 0.05 and 43.42 ± 0.62 µg/mL, respectively, outperforming ascorbic acid (58.46 ± 0.8 µg/mL). Total antioxidant capacity values (gAAE/100 g) were 36.04 ± 1.43 for the hetmethanol extract and 31.35 ± 3.98 for the petroleum extract. The extracts also exhibited potent anthelmintic activity, surpassing mebendazole at all tested concentrations for example the death time at 6mg/mL are 2min 05s, 4min 16s and 8min 33s respectively for the methanol extract, pet-ether extract and mebendazole. Both extracts showed broad antimicrobial effects, with minimum inhibition concentrations, 0.0122 to 25 mg/mL, and demonstrated notable anti-inflammatory properties. Thin-layer chromatographic profiling revealed four spots in the methanolic extract and seven in the petroleum ether extract, suggesting chemical diversity between the solvent fractions. FTIR spectra confirmed the presence of functional groups consistent with the compounds detected through phytochemical screening. The results indicate that the methanol and petroleum ether extracts of M. amoenum possess significant antioxidant, anti-inflammatory, antimicrobial and anthelmintic activities, supporting their potential as therapeutic effect.
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Claims 6
Claim · model-written summary
Pulverized Memecylon amoenum plant material contained twelve phytochemical constituents.
- Taxon
- Memecylon amoenumMemecylon amoenume1
- Outcome
- constituentse0
- Value
- twelvee0
Verbatim
e0“Phytochemical investigations revealed twelve constituents in the pulverized plant material”
e1“Memecylon amoenum”
Claim · model-written summary
The methanolic extract contained eleven constituents.
- Taxon
- Memecylon amoenumMemecylon amoenume1
- Material
- methanolic extracte0
- Outcome
- constituentse2
- Value
- elevene0
Verbatim
e0“eleven in the methanolic extract”
e1“Memecylon amoenum”
e2“Phytochemical investigations revealed twelve constituents in the pulverized plant material”
Claim · model-written summary
The petroleum ether extract contained six constituents.
- Taxon
- Memecylon amoenumMemecylon amoenume2
- Material
- petroleum ether extracte0
- Outcome
- constituentse1
- Value
- sixe0
Verbatim
e0“the petroleum ether extract contained six”
e1“Phytochemical investigations revealed twelve constituents in the pulverized plant material and eleven in the methanolic extract, while the petroleum ether extract contained six.”
e2“Memecylon amoenum”
Claim · model-written summary
Thin-layer chromatography showed four spots for the methanolic extract.
- Taxon
- Memecylon amoenumMemecylon amoenume1
- Material
- methanolic extracte0
- Outcome
- spotse0
- Value
- foure0
Verbatim
e0“four spots in the methanolic extract”
e1“Memecylon amoenum”
Claim · model-written summary
Thin-layer chromatography showed seven spots for the petroleum ether extract.
- Taxon
- Memecylon amoenumMemecylon amoenume2
- Material
- petroleum ether extracte0
- Outcome
- spotse1
- Value
- sevene0
Verbatim
e0“seven in the petroleum ether extract”
e1“Thin-layer chromatographic profiling revealed four spots in the methanolic extract and seven in the petroleum ether extract”
e2“Memecylon amoenum”
Claim · model-written summary
FTIR spectra confirmed functional groups consistent with the detected compounds.
- Taxon
- Memecylon amoenumMemecylon amoenume1
- Outcome
- presence of functional groupse0
Verbatim
e0“FTIR spectra confirmed the presence of functional groups consistent with the compounds detected through phytochemical screening”
e1“Memecylon amoenum”