Abstract
Three undescribed xanthonolignoids (1–3), together with eight known analogs (4–11), were isolated from Hypericum curvisepalum. Their structures were elucidated by mass and NMR spectroscopic analyses. In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively. Furthermore, the three new compounds dose-dependently inhibited biofilm formation and significantly suppressed both swimming and swarming motility of C. violaceum ATCC 12472.
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Claims 9
Claim · model-written summary
Three undescribed xanthonolignoids were isolated from Hypericum curvisepalum.
- Taxon
- Hypericum curvisepalumHypericum curvisepalume0
- Outcome
- Three undescribed xanthonolignoidse0
- Value
- 1–3e0
Verbatim
e0“Three undescribed xanthonolignoids (1–3), together with eight known analogs (4–11), were isolated from Hypericum curvisepalum.”
Claim · model-written summary
Eight known analogs were isolated from Hypericum curvisepalum.
- Taxon
- Hypericum curvisepalumHypericum curvisepalume0
- Outcome
- eight known analogse0
- Value
- 4–11e0
Verbatim
e0“Three undescribed xanthonolignoids (1–3), together with eight known analogs (4–11), were isolated from Hypericum curvisepalum.”
Claim · model-written summary
Compound 1 inhibited violacein production by 84.92% in the bacterial bioassay.
Verbatim
e0“In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively.”
Claim · model-written summary
Compound 4 inhibited violacein production by 74.96% in the bacterial bioassay.
Verbatim
e0“In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively.”
Claim · model-written summary
Compound 6 inhibited violacein production by 70.47% in the bacterial bioassay.
Verbatim
e0“In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively.”
Claim · model-written summary
Compound 7 inhibited violacein production by 71.43% in the bacterial bioassay.
Verbatim
e0“In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively.”
Claim · model-written summary
Compound 9 inhibited violacein production by 76.87% in the bacterial bioassay.
Verbatim
e0“In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively.”
Claim · model-written summary
The three new compounds inhibited bacterial biofilm formation with dose.
- Taxon
- C. violaceum ATCC 12472
Chromobacterium violaceume0 - Material
- the three new compoundse0
- Outcome
- biofilm formatione0
- Direction
- inhibitede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Furthermore, the three new compounds dose-dependently inhibited biofilm formation and significantly suppressed both swimming and swarming motility of C. violaceum ATCC 12472.”
Claim · model-written summary
The three new compounds suppressed bacterial swimming and swarming motility.
- Taxon
- C. violaceum ATCC 12472Chromobacterium violaceume0
- Material
- the three new compoundse0
- Outcome
- swimming and swarming motilitye0
- Direction
- suppressede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Furthermore, the three new compounds dose-dependently inhibited biofilm formation and significantly suppressed both swimming and swarming motility of C. violaceum ATCC 12472.”